OBJECTIVES The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects without heart disease. DESIGN The relationship between concentrations of 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease. RESULTS Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL(-1) ; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D < 20 ng mL(-1) ]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, P < 0.05) and LV mass index (β 7.5, SE 2.6, P < 0.01). A significant nonlinear relation between 25(OH)D and LV concentric remodelling was observed. LV remodelling was more likely in participants with 25(OH)D levels <30 ng mL(-1) [odds ratio (OR) 1.24; 95% confidence interval (CI) 0.83-1.85] or ≥38 ng mL(-1) (OR 1.73; 95% CI 1.13-2.65), compared with those with 30-37 ng mL(-1) 25(OH)D. Consistently, LV relative wall thickness was significantly lower (P for trend=0.05), and LV diastolic internal diameter index (P for trend<0.05) and end-diastolic volume index (P for trend<0.05) were significantly higher in subjects with 30-37 ng mL(-1) 25(OH)D compared to the rest of the study population. There was a significant interaction between 25(OH)D and hypertension on the risk of LV hypertrophy (P < 0.05). CONCLUSIONS In a population-based sample of predominantly vitamin D-sufficient subjects without heart disease, LV geometry was most favourable at intermediate 25(OH)D concentrations.

中文翻译：

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健康人群中维生素 D 状态与左心室几何形状之间的关系：巴尔的摩衰老纵向研究的结果。

目的 已经在心脏病患者中研究了维生素 D 对心脏的影响，但未在健康人中进行研究。我们在没有心脏病的社区居民中调查了维生素 D 状态与左心室 (LV) 结构和功能之间的关系。设计 在巴尔的摩衰老纵向研究的 711 名没有心脏病的参与者中，分析了 25-羟基维生素 D [25(OH)D]（维生素 D 储备的标志物）浓度与 LV 经胸超声心动图测量值之间的关系。结果 研究人群中的平均 25(OH)D 为 32.3 ± 11.4 ng mL(-1)；只有 15.5% 的受试者患有中度或重度维生素 D 缺乏症 [25(OH)D < 20 ng mL(-1)]。调整年龄、体重指数、心血管疾病危险因素、身体活动、钙和甲状旁腺激素，25(OH)D 与 LV 厚度（β 0.095，SE 0.039，P < 0.05）和 LV 质量指数（β 7.5，SE 2.6，P < 0.01）呈正相关。观察到 25(OH)D 和 LV 同心重构之间存在显着的非线性关系。25(OH)D 水平 <30 ng mL(-1) [比值比 (OR) 1.24；95% 置信区间 (CI) 0.83-1.85] 或 ≥38 ng mL(-1)（OR 1.73；95% CI 1.13-2.65），与 30-37 ng mL(-1) 25(OH)D 相比. 始终如一地，LV 相对壁厚显着降低（趋势 P=0.05），LV 舒张内径指数（趋势 P<0.05）和舒张末期容积指数（趋势 P<0.05）在 30 -37 ng mL(-1) 25(OH)D 与其他研究人群相比。25(OH)D 和高血压对 LV 肥厚的风险有显着的交互作用（P < 0.05）。结论 在以维生素 D 充足且没有心脏病的人群为基础的样本中，LV 几何形状在中间 25(OH)D 浓度下最有利。