Parasitic helminth infection remains a global health problem, whilst the ability of worms to manipulate and dampen the host immune system is attracting interest in the fields of allergy and autoimmunity. Much progress has been made in the last two years in determining the cells and cytokines involved in induction of Type 2 immunity, which is generally protective against helminth infection. Innate cells respond to 'alarmin' cytokines (IL-25, IL-33, TSLP) by producing IL-4, IL-5 and IL-13, and this sets the stage for a more potent subsequent adaptive Th2 response. CD4+ Th2 cells then drive a suite of type 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate defence molecules; the concerted effects of these multiple pathways disable, degrade and dislodge parasites, leading to their destruction or expulsion.

中文翻译：

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对蠕虫寄生虫的易感性和免疫力。

寄生虫感染仍然是一个全球性的健康问题，而蠕虫操纵和抑制宿主免疫系统的能力正在引起过敏和自身免疫领域的兴趣。过去两年在确定参与 2 型免疫诱导的细胞和细胞因子方面取得了很大进展，2 型免疫通常对蠕虫感染具有保护作用。先天细胞通过产生 IL-4、IL-5 和 IL-13 对“警报”细胞因子（IL-25、IL-33、TSLP）作出反应，这为更有效的后续适应性 Th2 反应奠定了基础。CD4+ Th2 细胞然后驱动一套 2 型抗寄生虫机制，包括类别转换抗体、激活的白细胞和先天防御分子；这些多种途径的协同作用使寄生虫失能、降解和驱逐，