Transmission of Plasmodium from mosquito to the mammalian host leads to a clinically silent pre-erythrocytic stage of malaria infection, and subsequent cyclical erythrocytic invasion associated with disease. Recent evidence demonstrates that it is the interplay between CD4+ and CD8+ T cells, and the regulation of their response, throughout infection that dictates immunity and the pathogenesis of malaria. The elicited T cell response is context dependent, influenced by diverse host and parasite factors, necessitating the development of a unifying model of T cell potential during Plasmodium infection. Only then can we predict their capacity to dictate the outcome of human disease.

中文翻译：

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T细胞控制疟疾发病机制。

疟原虫从蚊子传播到哺乳动物宿主会导致疟疾感染的临床无症状前红细胞阶段，以及随后与疾病相关的周期性红细胞侵袭。最近的证据表明，在整个感染过程中，CD4+ 和 CD8+ T 细胞之间的相互作用及其反应的调节决定了免疫力和疟疾的发病机制。引发的 T 细胞反应取决于环境，受多种宿主和寄生虫因素的影响，因此需要在疟原虫感染期间开发统一的 T 细胞潜力模型。只有这样，我们才能预测它们决定人类疾病结果的能力。