The cell surface receptor Notch contributes to the development of nearly every tissue in most metazoans by controlling the fates and differentiation of cells. Recent results have now established that Notch also regulates the connectivity of the nervous system, and does so at a variety of levels, including specification of neuronal identity, division, survival and migration, as well as axon guidance, morphogenesis of dendritic arbors and weighting of synapse strength. To these ends, Notch engages at least two signal transduction pathways, one that controls nuclear gene expression and another that directly targets the cytoskeleton. Coordinating the many functions of Notch to produce neural structure is thus a pivotal aspect of building and maintaining the nervous system.

中文翻译：

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Notch 信号和神经连接。

细胞表面受体 Notch 通过控制细胞的命运和分化，促进了大多数后生动物中几乎所有组织的发育。最近的结果表明，Notch 还调节神经系统的连通性，并在多个层面进行调节，包括神经元身份、分裂、存活和迁移的规范，以及轴突引导、树突乔木的形态发生和权重突触强度。为此，Notch 参与了至少两种信号转导途径，一种控制核基因表达，另一种直接靶向细胞骨架。因此，协调 Notch 的许多功能以产生神经结构是构建和维持神经系统的关键方面。