Gene therapy has great potential to bring tremendous changes in treatment of various diseases and disorders. However, one of the impediments to successful gene therapy is the inefficient delivery of genes to target tissues and the inability to monitor delivery of genes and therapeutic responses at the targeted site. The emergence of molecular imaging strategies has been pivotal in optimizing gene therapy; since it can allow us to evaluate the effectiveness of gene delivery noninvasively and spatiotemporally. Due to the unique physiochemical properties of nanomaterials, numerous functional nanoparticles show promise in accomplishing gene delivery with the necessary feature of visualizing the delivery. In this review, recent developments of nanoparticles for molecular imaging guided gene delivery are summarized.

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用于分子成像引导基因传递的功能纳米粒子

基因疗法具有巨大的潜力，可以给各种疾病和病症的治疗带来巨大的变化。然而，成功基因治疗的障碍之一是基因向靶组织的递送效率低下，并且无法监测靶位点的基因递送和治疗反应。分子成像策略的出现对于优化基因治疗至关重要。因为它可以让我们以非侵入性和时空方式评估基因传递的有效性。由于纳米材料独特的理化性质，许多功能性纳米粒子在完成基因传递方面显示出希望，并具有可视化传递的必要特征。在这篇综述中，总结了用于分子成像引导基因传递的纳米颗粒的最新进展。