Among the most intensively studied systems in molecular biology is the eukaryotic transcriptional apparatus, which expresses genes in a regulated manner across hundreds of different cell types. Several studies over the past few years have added weight to the concept that transcription takes place within discrete 'transcription factories' assembled inside the cell nucleus. These studies apply innovative technical approaches to gain insights into the molecular constituents, dynamical behaviour and organizational regulators of transcription factories, providing exciting insights into the spatial dimension of transcriptional control.

中文翻译：

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转录工厂：三个维度的基因编程。

分子生物学中研究最深入的系统之一是真核转录装置，它以受监管的方式在数百种不同的细胞类型中表达基因。过去几年的几项研究增加了转录发生在细胞核内组装的离散“转录工厂”的概念的重要性。这些研究应用创新的技术方法来深入了解转录工厂的分子成分、动力学行为和组织调节器，为转录控制的空间维度提供令人兴奋的见解。