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Helper T cell diversity and plasticity.
Current Opinion in Immunology ( IF 7 ) Pub Date : 2012-02-22 , DOI: 10.1016/j.coi.2012.01.014
Shingo Nakayamada 1 , Hayato Takahashi , Yuka Kanno , John J O'Shea
Affiliation  

CD4(+) helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4(+) T cell subsets have been viewed as terminally differentiated lineages with limited flexibility. However, following the recognition of new subsets, there is increased recognition of plasticity. In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4(+) T cell differentiation and plasticity.

中文翻译:

辅助 T 细胞多样性和可塑性。

CD4(+) 辅助性 T 细胞通过分化为专门的子集的能力,在宿主防御和免疫介导的疾病中发挥着至关重要的作用。这些亚群在响应微生物病原体时获得细胞因子分泌的受限模式和主转录因子的特异性表达。传统上,各种辅助 CD4(+) T 细胞亚群被视为具有有限灵活性的终末分化谱系。然而,随着新子集的识别,人们对可塑性的认识增加。在这篇评论中,我们重点介绍了与该主题相关的最新进展以及有助于 CD4(+) T 细胞分化和可塑性的机制。
更新日期:2012-02-15
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