Lymphocyte development requires cells to progress through a series of stages, each associated with changes in gene expression. Intense effort has been invested into characterising the dynamic networks of transcription factors underlying these regulated changes. Whilst transcription factors determine the tempo at which mRNA is produced, recent results highlight the importance of the selective regulation of mRNA decay and translation in regulating gene expression. These processes are regulated by sequence-specific RNA-binding proteins (RBP) as well as noncoding RNA such as microRNAs. RNA-binding proteins are emerging as important regulators of cell fate and function in both developing and mature lymphocytes. At the molecular level the function of RNA-binding proteins is integrated with signal transduction pathways that also govern gene transcription.

中文翻译：

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RNA结合蛋白对淋巴细胞发育和功能的调节。

淋巴细胞发育需要细胞经历一系列阶段，每个阶段都与基因表达的变化有关。已投入大量精力来表征这些受调控变化背后的转录因子的动态网络。虽然转录因子决定了 mRNA 产生的速度，但最近的结果强调了选择性调节 mRNA 衰变和翻译在调节基因表达中的重要性。这些过程受序列特异性 RNA 结合蛋白 (RBP) 以及非编码 RNA（如 microRNA）的调控。RNA 结合蛋白正在成为发育和成熟淋巴细胞中细胞命运和功能的重要调节剂。在分子水平上，RNA 结合蛋白的功能与控制基因转录的信号转导通路相结合。