Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals. Genome-wide association studies have confirmed that polymorphism within the HLA class I locus is the primary host genetic contributor to determining outcome after infection. Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effects of HLA molecules in viral disease become apparent.

中文翻译：

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自发控制 HIV 的免疫遗传学。

目前估计宿主遗传变异约占感染个体之间 HIV 控制差异的四分之一。全基因组关联研究证实，HLA I 类基因座内的多态性是决定感染后结果的主要宿主遗传因素。在这里，我们超越了单独的遗传关联来考虑这些相关性的功能解释。在这个过程中，HLA 分子在病毒性疾病中的复杂和多维效应变得明显。