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How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability
Maturitas ( IF 4.9 ) Pub Date : 2011-08-01 , DOI: 10.1016/j.maturitas.2011.05.010
Lawrence J Whalley 1 , Alison D Murray , Roger T Staff , John M Starr , Ian J Deary , Helen C Fox , Helen Lemmon , Susan J Duthie , Andrew R Collins , John R Crawford
Affiliation  

OBJECTIVES To describe the discovery and development of the Aberdeen 1921 and 1936 birth cohort studies. STUDY DESIGN The Aberdeen birth cohort studies were started in 1998 when the Scottish Mental Survey archives of the Scottish Council for Research in Education were re-discovered and permissions granted to follow-up survivors born in 1921 or 1936 and then aged about 77 or 64 years and who had entered (or were about to enter) the age of greatest risk for Alzheimer's disease (AD). MAIN OUTCOME MEASURES Sources of attrition from the study, exposures to childhood adversity, nutritional, genetic and life style factors of possible relevance to extent of age-related cognitive decline and the timing of onset of dementia. RESULTS By 2010, the feasibility of following up more than 75% of Scottish Mental Survey survivors living in the Aberdeen area without dementia was well-established, dementia ascertainment to age about 88 years was completed in the 1921 birth cohort and was underway in the 1936 born cohort. CONCLUSION These databases are available to other bone fide research groups wishing to test specific hypotheses that may either replicate their own findings or make best use of the data collected in the Aberdeen studies.

中文翻译:

1932 年和 1947 年对阿伯丁学童的心理调查如何提供一个框架来探索迟发性疾病和残疾的儿童起源

目的 描述 Aberdeen 1921 年和 1936 年出生队列研究的发现和发展。研究设以及谁已经进入(或即将进入)阿尔茨海默病 (AD) 风险最高的年龄。主要结果测量 研究的减员来源、童年逆境的暴露、营养、遗传和生活方式因素可能与年龄相关的认知衰退程度和痴呆发作的时间相关。结果 到 2010 年,对居住在阿伯丁地区的 75% 以上的苏格兰精神调查幸存者进行随访而没有痴呆的可行性已得到充分证实,在 1921 年出生的队列中完成了 88 岁左右的痴呆确定,并在 1936 年出生的队列中进行。结论 这些数据库可供希望测试特定假设的其他骨干研究小组使用,这些假设可以复制他们自己的发现或充分利用阿伯丁研究中收集的数据。
更新日期:2011-08-01
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