BACKGROUND Haematological abnormalities are important to detect. In older adults there are few data that inform about normal ranges and the change in blood cell counts with ageing. These few data indicate that sex differences in blood cell counts persist beyond 70 years. OBJECTIVE To determine normal ranges for blood cell counts and changes in counts and to examine the relationship between different blood cell counts for men and women. METHODS The sample comprised Lothian Birth Cohort 1921 (LBC1921) participants seen at a mean of about 79 and 87 years of age. Full blood count was measured on each occasion. Also recorded were weight, smoking status, years of full-time education, and main occupation, serum B12, folate and creatinine. RESULTS We examined blood cell counts in 495 community-resident people with mean age 79.1 (range 77.8-80.6) and repeated this in 157 of them at mean age 86.7 (range 85.7-87.4) years. Normal ranges were similar for men and women for all blood cell types at both ages, but men had persistently significantly higher mean red cell and monocyte counts, and women significantly higher platelet counts. Between 79 and 87 years, red cell, lymphocyte and eosinophil counts fell significantly, neutrophil and platelet counts increased, and monocyte count was stable. Worsening renal function was associated with a decrease in mean red cell count. CONCLUSION Changes in blood cell counts in this cohort are consistent with persistent sex differences, age-related changes in renal function (red cells), background inflammation (neutrophils and platelets) and immunosenescence (lymphocytes).

中文翻译：

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Lothian Birth Cohort 1921 年 79 至 87 岁之间血细胞计数的性别差异

背景血液学异常对于检测很重要。在老年人中，很少有数据可以说明正常范围和血细胞计数随年龄增长的变化。这些少数数据表明，血细胞计数的性别差异持续超过 70 年。目的 确定血细胞计数的正常范围和计数变化，并检查男性和女性不同血细胞计数之间的关系。方法 样本包括 Lothian Birth Cohort 1921 (LBC1921) 参与者，平均年龄约为 79 和 87 岁。每次测量全血细胞计数。还记录了体重、吸烟状况、全日制教育年限、主要职业、血清 B12、叶酸和肌酐。结果 我们检查了 495 名平均年龄为 79.1 岁（范围 77.8-80.0 岁）的社区居民的血细胞计数。6）并在平均年龄 86.7（范围 85.7-87.4）岁的 157 人中重复此操作。男性和女性在两个年龄段的所有血细胞类型的正常范围相似，但男性的平均红细胞和单核细胞计数持续显着升高，女性的血小板计数显着升高。79-87岁之间，红细胞、淋巴细胞和嗜酸性粒细胞计数明显下降，中性粒细胞和血小板计数增加，单核细胞计数稳定。肾功能恶化与平均红细胞计数减少有关。结论 该队列中血细胞计数的变化与持续的性别差异、肾功能（红细胞）、背景炎症（中性粒细胞和血小板）和免疫衰老（淋巴细胞）的年龄相关变化一致。男性和女性在两个年龄段的所有血细胞类型的正常范围相似，但男性的平均红细胞和单核细胞计数持续显着升高，女性的血小板计数显着升高。79-87岁之间，红细胞、淋巴细胞和嗜酸性粒细胞计数明显下降，中性粒细胞和血小板计数增加，单核细胞计数稳定。肾功能恶化与平均红细胞计数减少有关。结论 该队列中血细胞计数的变化与持续的性别差异、肾功能（红细胞）、背景炎症（中性粒细胞和血小板）和免疫衰老（淋巴细胞）的年龄相关变化一致。男性和女性在两个年龄段的所有血细胞类型的正常范围相似，但男性的平均红细胞和单核细胞计数持续显着升高，女性的血小板计数显着升高。79-87岁之间，红细胞、淋巴细胞和嗜酸性粒细胞计数明显下降，中性粒细胞和血小板计数增加，单核细胞计数稳定。肾功能恶化与平均红细胞计数减少有关。结论 该队列中血细胞计数的变化与持续的性别差异、肾功能（红细胞）、背景炎症（中性粒细胞和血小板）和免疫衰老（淋巴细胞）的年龄相关变化一致。和女性血小板计数明显升高。79-87岁之间，红细胞、淋巴细胞和嗜酸性粒细胞计数明显下降，中性粒细胞和血小板计数增加，单核细胞计数稳定。肾功能恶化与平均红细胞计数减少有关。结论 该队列中血细胞计数的变化与持续的性别差异、肾功能（红细胞）、背景炎症（中性粒细胞和血小板）和免疫衰老（淋巴细胞）的年龄相关变化一致。和女性血小板计数明显升高。79-87岁之间，红细胞、淋巴细胞和嗜酸性粒细胞计数明显下降，中性粒细胞和血小板计数增加，单核细胞计数稳定。肾功能恶化与平均红细胞计数减少有关。结论 该队列中血细胞计数的变化与持续的性别差异、肾功能（红细胞）、背景炎症（中性粒细胞和血小板）和免疫衰老（淋巴细胞）的年龄相关变化一致。