Fungal diseases have emerged as significant causes of morbidity and mortality, particularly in immune-compromised individuals, prompting greater interest in understanding the mechanisms of host resistance to these pathogens. Consequently, the past few decades have seen a tremendous increase in our knowledge of the innate and adaptive components underlying the protective (and nonprotective) mechanisms of antifungal immunity. What has emerged from these studies is that phagocytic cells are essential for protection and that defects in these cells compromise the host's ability to resist fungal infection. This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens to subvert these defenses.

中文翻译：

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先天抗真菌免疫：吞噬细胞的关键作用。

真菌病已成为发病率和死亡率的重要原因，特别是在免疫功能低下的个体中，这促使人们更加关注了解宿主对这些病原体的抵抗机制。因此，在过去的几十年里，我们对抗真菌免疫保护（和非保护）机制背后的先天性和适应性成分的了解有了巨大的增长。从这些研究中得出的结论是，吞噬细胞对于保护至关重要，并且这些细胞中的缺陷会损害宿主抵抗真菌感染的能力。这篇综述涵盖了吞噬细胞在先天抗真菌免疫中的功能，以及真菌病原体用来破坏这些防御的策略的精选示例。