Accurate chromosome segregation is a prerequisite for the maintenance of the genomic stability. Consequently, elaborate molecular machineries and mechanisms emerged during the course of evolution in order to ensure proper division of the genetic material. The kinetochore, an essential multiprotein complex assembled on mitotic or meiotic centromeres, is an example of such machinery. Recently considerable progress has been made in understanding their composition, the recruitment hierarchy of their components, and the principles of their regulation. However, these advances are accompanied by a growing number of unanswered questions about the function of the individual subunits and of how the structure of the different subcomplexes relates to function. Here we review our rapidly growing knowledge on interacting networks of structural and regulatory proteins of the metazoan mitotic kinetochore: its centromeric foundations, its structural core, its components that interact with spindle microtubules and the spindle assembly checkpoint.

中文翻译：

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动粒和着丝粒：长距离工作关系。

准确的染色体分离是维持基因组稳定性的先决条件。因此，在进化过程中出现了精心设计的分子机器和机制，以确保遗传物质的正确分割。动粒是一种在有丝分裂或减数分裂着丝粒上组装的基本多蛋白复合物，就是这种机制的一个例子。最近，在理解它们的组成、其组成部分的招聘层次以及它们的监管原则方面取得了相当大的进展。然而，这些进步伴随着越来越多的未解决的问题，这些问题涉及单个亚基的功能以及不同亚复合体的结构如何与功能相关。