Parafibromin is a predominantly nuclear protein with a tumour suppressor role in the development of hereditary and nonhereditary parathyroid carcinomas, and the hyperparathyroidism-jaw tumour syndrome, which is associated with renal and uterine tumours. Parafibromin is a component of the highly conserved PAF1 complex, which regulates transcriptional events and histone modifications. The parafibromin/PAF1 complex regulates genes involved in cell growth and survival, and via these, parafibromin plays a pivotal role in embryonic development and survival of adults.

中文翻译：

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副纤维蛋白——功能见解。

副纤维蛋白主要是一种核蛋白，在遗传性和非遗传性甲状旁腺癌以及与肾和子宫肿瘤相关的甲状旁腺功能亢进-颌骨肿瘤综合征的发展中具有抑癌作用。副纤维蛋白是高度保守的 PAF1 复合物的一个组成部分，它调节转录事件和组蛋白修饰。副纤维蛋白/PAF1 复合物调节参与细胞生长和存活的基因，通过这些，副纤维蛋白在成人的胚胎发育和存活中发挥关键作用。