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Body mass index trajectories and age at menopause in a British birth cohort
Maturitas ( IF 4.9 ) Pub Date : 2008-04-01 , DOI: 10.1016/j.maturitas.2008.02.009
Rebecca Hardy 1 , Gita D Mishra , Diana Kuh
Affiliation  

Objective This study investigates the influence of body mass index (BMI) at ages 15, 20, 26, 36, and 43, and of BMI trajectories from 20 to 36 years on the timing of menopause and hormone therapy (HT) use until age 57 years. Methods A nationally representative British cohort of 1583 women born in March 1946 with prospective data across the life course. Results By age 57, a total of 695 women had experienced natural menopause while 431 women had started HT prior to menopause. Cox regression models indicated no significant associations between BMI at any age, or BMI trajectory, and timing of natural menopause. At every age BMI was strongly (p ≤ 0.01) and linearly associated with age at HT use and BMI from 26 years onwards was associated with age at first event (menopause or HT use). Decreasing BMI was associated with earlier HT use at all ages. These associations were not accounted for by parity, cigarette smoking or childhood and adult social class. Conclusion BMI across the reproductive lifespan did not influence age at menopause to an extent that would be clinically relevant for postmenopausal health. Lower BMI at all ages and underweight trajectory were related to an earlier start of HT. Further studies are required to understand whether such relationships are due to underweight women experiencing menopause earlier (and because of menopausal symptoms starting HT earlier) than heavier women, or having behavioural characteristics related to earlier HT use, independent of menopause.

中文翻译:

英国出生队列中的体重指数轨迹和更年期年龄

目的 本研究调查 15、20、26、36 和 43 岁的体重指数 (BMI) 以及 20 至 36 岁的 BMI 轨迹对 57 岁之前绝经和激素治疗 (HT) 使用时间的影响年。方法 1583 名出生于 1946 年 3 月的英国女性具有全国代表性的队列,其中包含整个生命历程的前瞻性数据。结果 到 57 岁时,共有 695 名女性经历了自然更年期,而 431 名女性在更年期前开始接受激素治疗。Cox 回归模型表明任何年龄的 BMI 或 BMI 轨迹与自然绝经时间之间没有显着关联。在每个年龄,BMI 都很强 (p ≤ 0.01) 并且与使用 HT 的年龄呈线性相关,26 岁以后的 BMI 与首次事件(更年期或使用 HT)的年龄相关。降低 BMI 与所有年龄段早期使用 HT 相关。这些关联没有被平价、吸烟或儿童和成人社会阶层解释。结论 整个生殖寿命期间的 BMI 不会影响绝经年龄,其程度与绝经后健康临床相关。所有年龄段的较低 BMI 和体重过轻的轨迹与较早开始 HT 相关。需要进一步的研究来了解这种关系是否是由于体重不足的女性比体重较重的女性更早经历更年期(并且因为更年期症状开始更早),或者具有与更年期使用相关的行为特征,与更年期无关。结论 整个生殖寿命期间的 BMI 不会影响绝经年龄,其程度与绝经后健康临床相关。所有年龄段的较低 BMI 和体重过轻的轨迹与较早开始 HT 相关。需要进一步的研究来了解这种关系是否是由于体重不足的女性比体重较重的女性更早经历更年期(并且因为更年期症状开始更早),或者具有与更年期使用相关的行为特征,与更年期无关。结论 整个生殖寿命期间的 BMI 不会影响绝经年龄,其程度与绝经后健康临床相关。所有年龄段的较低 BMI 和体重过轻的轨迹与较早开始 HT 相关。需要进一步的研究来了解这种关系是否是由于体重不足的女性比体重较重的女性更早经历更年期(并且因为更年期症状开始更早),或者具有与更年期使用相关的行为特征,与更年期无关。
更新日期:2008-04-01
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