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Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating.
Annual Review of Physiology ( IF 18.2 ) Pub Date : 2020-02-10 , DOI: 10.1146/annurev-physiol-020518-114349
Jianhua Zhang 1 , John C Chatham 1 , Martin E Young 2
Affiliation  

On Earth, all life is exposed to dramatic changes in the environment over the course of the day; consequently, organisms have evolved strategies to both adapt to and anticipate these 24-h oscillations. As a result, time of day is a major regulator of mammalian physiology and processes, including transcription, signaling, metabolism, and muscle contraction, all of which oscillate over the course of the day. In particular, the heart is subject to wide fluctuations in energetic demand throughout the day as a result of waking, physical activity, and food intake patterns. Daily rhythms in cardiovascular function ensure that increased delivery of oxygen, nutrients, and endocrine factors to organs during the active period and the removal of metabolic by-products are in balance. Failure to maintain these physiologic rhythms invariably has pathologic consequences. This review highlights rhythms that underpin cardiac physiology. More specifically, we summarize the key aspects of cardiac physiology that oscillate over the course of the day and discuss potential mechanisms that regulate these 24-h rhythms.

中文翻译:

生理生理的昼夜节律:保持心脏跳动的节律。

在地球上,所有生命在一天当中都会遭受环境急剧变化的影响;因此,生物体已经进化出适应和预测这些24小时振荡的策略。结果,一天中的时间是哺乳动物生理和过程的主要调节者,包括转录,信号传导,新陈代谢和肌肉收缩,所有这些在一天中都会发生振荡。尤其是,由于清醒,体育锻炼和食物摄入方式的影响,心脏全天能量需求的波动很大。心血管功能的日常节律可确保在活动期间增加向器官的氧气,营养素和内分泌因子的输送,并平衡代谢副产物的去除。无法维持这些生理节律总是会导致病理后果。这篇评论突出了支撑心脏生理的节律。更具体地说,我们总结了一天中振荡的心脏生理学的关键方面,并讨论了调节这些24小时节律的潜在机制。
更新日期:2020-04-21
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