Neuroanatomy suggests that adjacent neocortical neurons share a similar set of afferent synaptic inputs, as opposed to neurons localized to different areas of the neocortex. In the present study, we made simultaneous single-electrode patch clamp recordings from two or three adjacent neurons in the primary somatosensory cortex (S1) of the ketamine-xylazine anesthetized rat in vivo to study the correlation patterns in their spike firing during both spontaneous and sensory-evoked activity. One difference with previous studies of pairwise neuronal spike firing correlations was that here we identified several different quantifiable parameters in the correlation patterns by which different pairs could be compared. The questions asked were if the correlation patterns between adjacent pairs were similar and if there was a relationship between the degree of similarity and the layer location of the pairs. In contrast, our results show that for putative pyramidal neurons within layer III and within layer V, each pair of neurons is to some extent unique in terms of their spiking correlation patterns. Interestingly, our results also indicated that these correlation patterns did not substantially alter between spontaneous and evoked activity. Our findings are compatible with the view that the synaptic input connectivity to each neocortical neuron is at least in some aspects unique. A possible interpretation is that plasticity mechanisms, which could either be initiating or be supported by transcriptomic differences, tend to differentiate rather than harmonize the synaptic weight distributions between adjacent neurons of the same type.

中文翻译：

---

体内相邻的新皮层神经元对之间没有重复相关模式。

神经解剖学表明，与位于新皮层不同区域的神经元相反，相邻的新皮层神经元共享一组相似的突触输入。在本研究中，我们从氯胺酮-甲苯噻嗪麻醉的大鼠的初级体感皮层（S1）的两个或三个相邻神经元中，同时进行了单电极膜片钳记录，以研究自发性和自发性麻醉期间它们的峰值放电的相关模式。感觉诱发的活动。与以前的成对神经元突波发射相关性研究的一个区别是，这里我们在相关性模式中确定了几个不同的可量化参数，通过它们可以比较不同的对。提出的问题是，相邻对之间的相关模式是否相似，以及相似度与对的层位置之间是否存在关系。相反，我们的结果表明，对于第III层和第V层内的假定锥体神经元，每对神经元在其尖峰相关模式方面在某种程度上都是唯一的。有趣的是，我们的结果还表明，这些相关模式在自发活动和诱发活动之间基本没有改变。我们的发现与至少在某些方面唯一的新皮质神经元的突触输入连接性观点相符。一种可能的解释是，可塑性机制可能是转录组差异的起源或支持，