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Healing of Chronic Wounds: An Update of Recent Developments and Future Possibilities.
Tissue Engineering, Part B: Reviews ( IF 6.4 ) Pub Date : 2019-09-11 , DOI: 10.1089/ten.teb.2019.0019 Mustafa Hussain Kathawala 1 , Wei Long Ng 2 , Dan Liu 3 , May Win Naing 3 , Wai Yee Yeong 2 , Kara L Spiller 4 , Mark Van Dyke 5 , Kee Woei Ng 1, 6, 7
Tissue Engineering, Part B: Reviews ( IF 6.4 ) Pub Date : 2019-09-11 , DOI: 10.1089/ten.teb.2019.0019 Mustafa Hussain Kathawala 1 , Wei Long Ng 2 , Dan Liu 3 , May Win Naing 3 , Wai Yee Yeong 2 , Kara L Spiller 4 , Mark Van Dyke 5 , Kee Woei Ng 1, 6, 7
Affiliation
Chronic wounds are the result of disruptions in the body's usual process of healing. They are not only a source of significant pain and discomfort but also, more importantly, an unguarded port of entry for pathogens into the body. While our current understanding of this phenomenon is far from complete, findings in physiological patterns and advancements in wound healing technologies have helped develop wound management and healing solutions to this long-standing medical challenge. This review presents an overview of known wound healing mechanics, abnormalities that lead to chronic wounds, and a summary of established and new wound healing technologies. Various approaches to heal wounds are discussed, from dermal replacements to advanced biomaterial-based treatments, from cell-, synthetic-, and composite-based approaches to preclinical approaches, which make developing such products possible. While tested breakthrough products are described, the authors focused more on recently developed innovations, which are at varying stages of maturity. The review concludes with a note on future perspectives and opinions on where the field and industry are headed and where they should be. Impact Statement Wound healing is an important area of research and clinical practice, and has captured the attention of tissue engineers since the nascent beginnings of the discipline. Tissue-engineered skin was the first FDA-approved product, achieved in 1996. Despite this success, and the passage of time, healing wounds, particularly chronic wounds, remains a vexing challenge. This comprehensive review article will provide readers with a synopsis of current issues, research approaches, animal models, technologies, and products that span the continuum from early development to clinical studies, in the hope of fueling new interests and ideas to overcome this long-standing medical challenge.
中文翻译:
慢性伤口的治疗:最新进展和未来可能性的更新。
慢性伤口是人体正常愈合过程中断的结果。它们不仅造成严重的疼痛和不适,而且更重要的是,病原体进入人体的不受保护的进入口。尽管我们目前对这种现象的了解还远远不够,但是生理模式的发现和伤口愈合技术的进步已经帮助开发了针对这一长期医学挑战的伤口处理和愈合解决方案。这篇综述概述了已知的伤口愈合机制,导致慢性伤口的异常情况,以及已建立和新的伤口愈合技术的摘要。讨论了各种治疗伤口的方法,从真皮替代到先进的基于生物材料的治疗,从细胞,合成,以及基于复合材料的临床前方法,这使得开发此类产品成为可能。在介绍经过测试的突破性产品时,作者将更多精力放在了处于不同成熟阶段的最新开发的创新上。回顾以关于未来的观点和观点的注释作为结尾,有关领域和行业的发展方向和方向。影响陈述伤口愈合是研究和临床实践的重要领域,自该学科诞生之初就引起了组织工程师的关注。组织工程皮肤是1996年获得FDA批准的首个产品。尽管取得了成功,并且随着时间的流逝,愈合伤口(尤其是慢性伤口)仍然是一个艰巨的挑战。
更新日期:2019-11-01
中文翻译:
慢性伤口的治疗:最新进展和未来可能性的更新。
慢性伤口是人体正常愈合过程中断的结果。它们不仅造成严重的疼痛和不适,而且更重要的是,病原体进入人体的不受保护的进入口。尽管我们目前对这种现象的了解还远远不够,但是生理模式的发现和伤口愈合技术的进步已经帮助开发了针对这一长期医学挑战的伤口处理和愈合解决方案。这篇综述概述了已知的伤口愈合机制,导致慢性伤口的异常情况,以及已建立和新的伤口愈合技术的摘要。讨论了各种治疗伤口的方法,从真皮替代到先进的基于生物材料的治疗,从细胞,合成,以及基于复合材料的临床前方法,这使得开发此类产品成为可能。在介绍经过测试的突破性产品时,作者将更多精力放在了处于不同成熟阶段的最新开发的创新上。回顾以关于未来的观点和观点的注释作为结尾,有关领域和行业的发展方向和方向。影响陈述伤口愈合是研究和临床实践的重要领域,自该学科诞生之初就引起了组织工程师的关注。组织工程皮肤是1996年获得FDA批准的首个产品。尽管取得了成功,并且随着时间的流逝,愈合伤口(尤其是慢性伤口)仍然是一个艰巨的挑战。