Introduction: By preventing nasopharyngeal carriage acquisition among vaccinated persons, and thus reducing transmission, pneumococcal conjugate vaccines (PCVs) provide protection against pneumococcal vaccine serotypes among unvaccinated individuals. This systematic review assessed PCVs containing serotype 19A or cross-reactive 19F for 19A carriage effects.Areas covered: Peer-reviewed literature was searched for manuscripts published between 1/1/2000 and 06/18/2018 assessing the impact of PCV on 19A carriage.Expert opinion: Fifty-five, 12, and 32 articles were identified for PCV7, PCV10, and PCV13, respectively. In two of four PCV7 randomized controlled trials (RCTs), 19A carriage was significantly higher in PCV7-vaccinated vs control subjects; in two of two PCV10 RCTs, there was no significant difference in 19A carriage and acquisition between PCV10-vaccinated (2 + 1 schedule) vs control subjects, apart from one timepoint (3 + 1 schedule); and one of one RCTs of PCV13 showed significant decreases in 19A carriage and acquisition in PCV13- vs PCV7-vaccinated (3 + 1 schedule) children. These findings were consistent with observational studies in which an increase or no change in 19A carriage was observed in 91% and 67% of PCV7 and PCV10 studies, respectively, whereas 87% of PCV13 studies documented a decrease. Countries in which serotype 19A transmission is substantial should consider the use of vaccines containing serotype 19A.

中文翻译：

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肺炎球菌结合疫苗对血清型19A鼻咽运输的影响。

简介：肺炎球菌结合疫苗（PCV）通过预防接种者之间的鼻咽运输，从而减少传播，为未接种疫苗的个体提供了针对肺炎球菌血清型的保护。该系统评价评估了血清型19A或交叉反应19F的PCV对19A运载的影响涵盖领域：检索同行评审文献以查找在2000年1月1日至2018年6月18日期间发表的手稿，以评估PCV对19A运载的影响专家意见：分别确定PCV7，PCV10和PCV13的文章为55、12和32。在四个PCV7随机对照试验（RCT）中的两个中，接种PCV7的受试者的19A转运明显高于对照组。在两个PCV10 RCT中的两个中，除一个时间点（3 + 1个时间表）外，接种PCV10疫苗（2 + 1个时间表）与对照组之间在19A运送和获取方面无显着差异；PCV13的一项随机对照试验之一显示，接种PCV13的儿童与接种PCV7的儿童（3 + 1计划）的19A携带和获得显着减少。这些发现与观察性研究一致，在观察性研究中，分别在91％和67％的PCV7和PCV10研究中观察到19A转运的增加或没有变化，而87％的PCV13研究表明减少了。血清型19A传播大量的国家应考虑使用含血清型19A的疫苗。PCV13的一项随机对照试验之一显示，接种PCV13的儿童与接种PCV7的儿童（3 + 1计划）的19A携带和获得显着减少。这些发现与观察性研究一致，在观察性研究中，分别在91％和67％的PCV7和PCV10研究中观察到19A转运的增加或没有变化，而87％的PCV13研究表明减少了。血清型19A传播大量的国家应考虑使用含血清型19A的疫苗。PCV13的一项随机对照试验之一显示，接种PCV13的儿童与接种PCV7的儿童（3 + 1计划）的19A携带和获得显着减少。这些发现与观察性研究一致，在观察性研究中，分别在91％和67％的PCV7和PCV10研究中观察到19A转运的增加或没有变化，而87％的PCV13研究表明减少了。血清型19A传播大量的国家应考虑使用含血清型19A的疫苗。