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Towards descriptor of elementary functions for protein design.
Current Opinion in Structural Biology ( IF 6.8 ) Pub Date : 2019-07-25 , DOI: 10.1016/j.sbi.2019.06.010
Igor N Berezovsky 1
Affiliation  

We review studies of the protein evolution that help to formulate rules for protein design. Acknowledging the fundamental importance of Dayhoff's provision on the emergence of functional proteins from short peptides, we discuss multiple evidences of the omnipresent partitioning of protein globules into structural/functional units, using which greatly facilitates the engineering and design efforts. Closed loops and elementary functional loops, which are descendants of ancient ring-like peptides that formed fist protein domains in agreement with Dayhoff's hypothesis, can be considered as basic units of protein structure and function. We argue that future developments in protein design approaches should consider descriptors of the elementary functions, which will help to complement designed scaffolds with functional signatures and flexibility necessary for their functions.

中文翻译:

迈向蛋白质设计基本功能的描述符。

我们审查蛋白质进化的研究,有助于制定蛋白质设计规则。认识到Dayhoff的规定对短肽中功能性蛋白质的出现的根本重要性,我们讨论了蛋白质球无处不在的划分为结构/功能单元的多种证据,从而大大促进了工程和设计工作。闭合环和基本功能环是古老的环状肽的后代,其与Dayhoff的假设一致,形成了第一个蛋白质结构域,可以被视为蛋白质结构和功能的基本单位。我们认为蛋白质设计方法的未来发展应考虑基本功能的描述,
更新日期:2019-11-01
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