Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen‐induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.

中文翻译：

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先天免疫在哮喘发展和保护中的作用：来自环境的教训

哮喘是一种以气道炎症、高反应性和重塑为特征的复杂慢性疾病，影响着全世界 3 亿多人。虽然该疾病通常与过度的过敏原诱导的 2 型免疫反应有关，但这些反应受到环境暴露的强烈影响，环境暴露会刺激能够促进或预防哮喘的先天免疫途径。先天免疫在哮喘发病机制中的双重作用为研究和临床干预提供了多种机会，也是本综述的主题。