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Preoperative neutrophil-lymphocyte ratio predicts the risk of microvascular invasion in hepatocellular carcinoma: A meta-analysis.
The International Journal of Biological Markers ( IF 2 ) Pub Date : 2019-09-11 , DOI: 10.1177/1724600819874487
Furong Zeng 1 , Bin Chen 2 , Jiling Zeng 1 , Zhiming Wang 1 , Liang Xiao 1 , Guangtong Deng 1
Affiliation  

BACKGROUND Preoperative estimation of microvascular invasion is of great significance for the clinical decision making in hepatocellular carcinoma. Neutrophil-lymphocyte ratio (NLR) has been reported to be correlated with the poor prognosis of hepatocellular carcinoma. However, the conclusions are conflicting on whether high preoperative NLR level is associated with the presence of microvascular invasion. AIM To evaluate the association between preoperative NLR level and the risk of microvascular invasion in hepatocellular carcinoma. METHODS Relevant studies were identified by searching PubMed and Embase through February 2019. Fixed or random models were applied to analyze the data based on the heterogeneity. Subgroup, sensitivity, and publication bias analyses were performed. Review Manager 5.3 and STATA software were used for the meta-analysis. RESULTS A total of 15 studies were eventually included in this meta-analysis. Pooled data based on retrospective cohort studies showed there are more hepatocellular carcinoma patients with vascular invasion (OR 1.74; 95% Cl 1.42, 2.12; P < 0.001) and microvascular invasion (OR 1.62 95% Cl 1.39, 1.89; P < 0.001) in the high NLR group than in the low NLR group. Of case-control studies, a higher preoperative NLR level was found in the microvascular invasion positive group than in the microvascular invasion negative group (OR 0.62; 95% Cl 0.35, 0.90; P < 0.001). The subgroup, sensitivity, and publication bias analyses did not change the results. CONCLUSION A higher preoperative NLR level is positively correlated with the risk of microvascular invasion in hepatocellular carcinoma.

中文翻译:

术前中性粒细胞 - 淋巴细胞比率预​​测肝细胞癌微血管侵袭的风险:一项荟萃分析。

背景技术术前评估微血管侵犯对于肝细胞癌的临床决策具有重要意义。据报道,中性粒细胞 - 淋巴细胞比率(NLR)与肝细胞癌的不良预后相关。然而,关于术前高 NLR 水平是否与微血管侵犯的存在相关,结论是相互矛盾的。目的评价肝细胞癌术前NLR水平与微血管侵犯风险的关系。方法 通过搜索 PubMed 和 Embase 到 2019 年 2 月,确定相关研究。基于异质性应用固定或随机模型分析数据。进行了亚组、敏感性和发表偏倚分析。使用 Review Manager 5.3 和 STATA 软件进行荟萃分析。结果 共有 15 项研究最终被纳入该荟萃分析。基于回顾性队列研究的汇总数据显示,有更多肝细胞癌患者出现血管侵犯(OR 1.74;95% Cl 1.42, 2.12;P < 0.001)和微血管侵犯(OR 1.62 95% Cl 1.39, 1.89;P < 0.001)高 NLR 组比低 NLR 组。在病例对照研究中,微血管浸润阳性组的术前 NLR 水平高于微血管浸润阴性组(OR 0.62;95% Cl 0.35,0.90;P < 0.001)。亚组、敏感性和发表偏倚分析没有改变结果。结论 较高的术前NLR水平与肝细胞癌微血管侵犯的风险呈正相关。
更新日期:2019-11-01
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