BACKGROUND miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed to explore the prognostic value of miR-142-3p. METHODS Total RNA was extracted from renal cell carcinoma specimens and the expression level of miR-142-3p was measured. Pearson Chi-square test, Kaplan-Meier analysis, as well as univariate and multivariate regression analysis were performed to determine the correlation between miR-142-3p and the prognosis of renal cell carcinoma patients. Receiver operating characteristic curves were constructed to evaluate the predictive efficiency of miR-142-3p for the prognosis of renal cell carcinoma patients. Data from The Cancer Genome Atlas (TCGA) were utilized to validate our findings. RESULTS Our results demonstrated that upregulation of miR-142-3p was correlated with shorter overall survival (P=0.002) and was, in the meantime, an independent prognostic factor for renal cell carcinoma patients (P=0.002). The receiver operating characteristic curve combining miR-142-3p expression with tumor stage showed an area under the curve of 0.633 (95% confidence interval 0.563, 0.702). The result of TCGA data was consistent with our findings. CONCLUSIONS Our results suggest miR-142-3p expression is correlated with poor prognosis of renal cell carcinoma patients and may serve as a prognostic biomarker in the future.

中文翻译：

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miR-142-3p 作为预测肾细胞癌患者术后不良预后的新型生物标志物。

背景 已证明miR-142-3p参与肿瘤发生和肾细胞癌的发展。本研究旨在探讨 miR-142-3p 的预后价值。方法从肾细胞癌标本中提取总RNA，测定miR-142-3p的表达水平。采用Pearson卡方检验、Kaplan-Meier分析以及​​单因素和多因素回归分析确定miR-142-3p与肾细胞癌患者预后的相关性。构建受试者工作特征曲线以评估 miR-142-3p 对肾细胞癌患者预后的预测效率。来自癌症基因组图谱（TCGA）的数据被用来验证我们的发现。结果 我们的研究结果表明，miR-142-3p 的上调与较短的总生存期相关（P=0.002），同时也是肾细胞癌患者的独立预后因素（P=0.002）。结合 miR-142-3p 表达与肿瘤分期的受试者工作特征曲线显示曲线下面积为 0.633（95% 置信区间 0.563, 0.702）。TCGA 数据的结果与我们的研究结果一致。结论 我们的研究结果表明 miR-142-3p 的表达与肾细胞癌患者的不良预后相关，并可能作为未来的预后生物标志物。结合 miR-142-3p 表达与肿瘤分期的受试者工作特征曲线显示曲线下面积为 0.633（95% 置信区间 0.563, 0.702）。TCGA 数据的结果与我们的研究结果一致。结论 我们的研究结果表明 miR-142-3p 的表达与肾细胞癌患者的不良预后相关，并可能作为未来的预后生物标志物。结合 miR-142-3p 表达与肿瘤分期的受试者工作特征曲线显示曲线下面积为 0.633（95% 置信区间 0.563, 0.702）。TCGA 数据的结果与我们的研究结果一致。结论 我们的研究结果表明 miR-142-3p 的表达与肾细胞癌患者的不良预后相关，并可能作为未来的预后生物标志物。