Metastatic disease is caused by the ability of cancer cells to reach distant organs and form secondary lesions at new locations. Dissemination of cancer cells depends on their migration plasticity – an ability to switch between motility modes driven by distinct molecular machineries. One of such switches is mesenchymal‐to‐amoeboid transition. Although mesenchymal migration of individual cells requires Arp2/3‐dependent actin polymerisation, amoeboid migration is characterised by a high level of actomyosin contractility and often involves the formation of membrane blebs. The acquisition of amoeboid motility by mesenchymal cells is often associated with enhanced metastasis.

中文翻译：

---

从间充质到基于泡的运动的转变主要表现在纤维肉瘤细胞的 CD133 阳性亚群中

转移性疾病是由癌细胞到达远处器官并在新位置形成继发性病变的能力引起的。癌细胞的传播取决于它们的迁移可塑性——一种在不同分子机制驱动的运动模式之间切换的能力。其中一个开关是间充质到变形虫的转变。尽管单个细胞的间充质迁移需要依赖 Arp2/3 的肌动蛋白聚合，但变形虫迁移的特点是高水平的肌动球蛋白收缩性，并且通常涉及膜泡的形成。间充质细胞对变形虫运动的获得通常与转移的增强有关。