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Medial prefrontal cortex in neurological diseases.
Physiological Genomics ( IF 4.6 ) Pub Date : 2019-08-02 , DOI: 10.1152/physiolgenomics.00006.2019
Pan Xu 1 , Ai Chen 2 , Yipeng Li 3 , Xuezhi Xing 1 , Hui Lu 1
Affiliation  

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information from numerous cortical and subcortical areas and converges updated information to output structures. It plays essential roles in the cognitive process, regulation of emotion, motivation, and sociability. Dysfunction of the mPFC has been found in various neurological and psychiatric disorders, such as depression, anxiety disorders, schizophrenia, autism spectrum disorders, Alzheimer's disease, Parkinson's disease, and addiction. In the present review, we summarize the preclinical and clinical studies to illustrate the role of the mPFC in these neurological diseases.

中文翻译:

神经疾病的前额叶内侧皮层。

内侧前额叶皮层(mPFC)是至关重要的皮质区域,它整合了来自众多皮质和皮质下区域的信息,并将更新后的信息聚合到输出结构中。它在认知过程,情绪调节,动机和社交能力中起着至关重要的作用。已经在多种神经和精神疾病中发现了mPFC的功能障碍,例如抑郁症,焦虑症,精神分裂症,自闭症谱系障碍,阿尔茨海默氏病,帕金森氏病和成瘾。在本综述中,我们总结了临床前和临床研究,以阐明mPFC在这些神经系统疾病中的作用。
更新日期:2019-11-01
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