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The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings.
Neuroimmunomodulation ( IF 2.4 ) Pub Date : 2018-09-25 , DOI: 10.1159/000492716
Diego B Rebouças 1, 2 , Francisco Diego Rabelo-da-Ponte 1, 2 , Rafael Massuda 1, 3 , Leticia S Czepielewski 1, 2 , Clarissa S Gama 4, 5
Affiliation  

BACKGROUND Verbal memory impairment may be considered an endophenotype in schizophrenia (SZ), also affecting the siblings of SZ subjects. Furthermore, the immune-inflammatory system response has an important modulatory effect on brain processes, especially on memory circuits. OBJECTIVE Investigating the relationship between TNF-α and IL-6 and memory performance in patients with SZ, their unaffected siblings (SB) and healthy controls (HC). METHODS 35 subjects with SZ, 36 SB, and 47 HC underwent a neurocognitive assessment for verbal memory by means of the revised Hopkins Verbal Learning Test (HVLT-R) in addition to serum cytokines analyses. RESULTS SZ patients performed worse in HVLT-R than SB and HC, but SB and HC were not different. Regarding the biomarker levels, we found significant results of TNF-α for both groups. However, we did not find differences between groups after multiple-comparisons analysis. There were no significant correlations between episodic verbal memory, TNF-α, and IL-6. CONCLUSION The results are compatible with the hypothesis that deficits in verbal memory of individuals with SZ could be secondary to inadequate functioning of cognitive processing areas, such as proactive cognitive control.

中文翻译:

精神分裂症患者及其未患兄弟姐妹细胞因子与言语记忆的关系。

背景技术言语记忆障碍可被视为精神分裂症(SZ)的内表型,也影响SZ受试者的兄弟姐妹。此外,免疫-炎症系统反应对大脑过程,特别是对记忆电路有重要的调节作用。目的研究SZ患者,未患病兄弟姐妹(SB)和健康对照者(HC)的TNF-α和IL-6与记忆力之间的关系。方法除血清细胞因子分析外,还通过修订的霍普金斯言语学习测验(HVLT-R)对35名SZ,36 SB和47 HC受试者进行了语言认知神经认知评估。结果SZ患者的HVLT-R表现较SB和HC差,但SB和HC并无差异。关于生物标志物的水平,我们发现两组的TNF-α的显着结果。然而,经过多重比较分析,我们没有发现组之间的差异。情节性言语记忆,TNF-α和IL-6之间无显着相关性。结论该结果与以下假设相吻合:SZ个体的言语记忆缺陷可能是认知加工区域功能不足(如主动认知控制)的继发因素。
更新日期:2019-11-01
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