Abstract Given the aging Baby Boomer generation, changes in cannabis legislation, and the growing acknowledgment of cannabis for its therapeutic potential, it is predicted that cannabis use in the older population will escalate. It is, therefore, important to determine the interaction between the effects of cannabis and aging. The aim of this report is to describe the link between cannabis use and the aging brain. Our review of the literature found few and inconsistent empirical studies that directly address the impact of cannabis use on the aging brain. However, research focused on long-term cannabis use points toward cumulative effects on multimodal systems in the brain that are similarly affected during aging. Specifically, the effects of cannabis and aging converge on overlapping networks in the endocannabinoid, opioid, and dopamine systems that may affect functional decline particularly in the hippocampus and prefrontal cortex, which are critical areas for memory and executive functioning. To conclude, despite the limited current knowledge on the potential interactive effects between cannabis and aging, evidence from the literature suggests that cannabis and aging effects are concurrently present across several neurotransmitter systems. There is a great need for future research to directly test the interactions between cannabis and aging.

中文翻译：

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大麻使用和衰老的相互作用：从分子到心灵

摘要 鉴于婴儿潮一代的老龄化、大麻立法的变化以及对大麻治疗潜力的日益认可，预计老年人群中的大麻使用将升级。因此，重要的是确定大麻的影响与衰老之间的相互作用。本报告的目的是描述大麻使用与大脑老化之间的联系。我们对文献的回顾发现，很少且不一致的实证研究直接解决了大麻使用对衰老大脑的影响。然而，专注于长期使用大麻的研究表明，大脑中的多模态系统会产生累积效应，这些系统在衰老过程中也会受到类似的影响。具体而言，大麻和衰老的影响集中在内源性大麻素、阿片类药物、和多巴胺系统可能会影响功能衰退，尤其是海马体和前额叶皮层，这是记忆和执行功能的关键区域。总而言之，尽管目前对大麻与衰老之间潜在相互作用的了解有限，但文献证据表明，大麻和衰老效应同时存在于多个神经递质系统中。未来的研究非常需要直接测试大麻与衰老之间的相互作用。文献中的证据表明，大麻和衰老效应同时存在于几个神经递质系统中。未来的研究非常需要直接测试大麻与衰老之间的相互作用。文献中的证据表明，大麻和衰老效应同时存在于几个神经递质系统中。未来的研究非常需要直接测试大麻与衰老之间的相互作用。