OBJECTIVES To assess the delayed (15 days) histological and ultrastructural changes occurring following endovascular treatment with a direct aspiration first pass technique (ADAPT) or stent retrievers (SRs) and to compare the findings in order to determine which is the least harmful technique and what changes occur. MATERIALS AND METHODS Damage to the wall of swine extracranial arteries was evaluated after ADAPT with the Penumbra system or thrombectomy with various SRs. The procedures were performed using two pigs as animal models; extracranial cervical arteries were selected based on their diameters in order to reproduce the procedures as in human intracranial arteries, and endovascular thrombectomies were done after the injection of autologous thrombi. Two weeks later, the animals were euthanized, and 60 arterial samples were obtained for analysis by optical and electron microscopy. RESULTS Optical and electron microscopy revealed that both techniques cause, in different way, alterations to the structure of the vessel wall. CONCLUSIONS Both techniques caused damage to the vessel wall. The main damages were localized at the level of the tunica media and adventitia, instead of the tunica intima as in the acute phase. Further investigation is required to better understand whether these alterations could have chronic consequences.

中文翻译：

---

急性缺血性卒中血栓切除术后 ADAPT 与支架取栓装置引起的亚急性血管损伤的比较：动物模型的组织学和超微结构研究。

目的 评估使用直接抽吸首次通过技术 (ADAPT) 或支架取栓器 (SRs) 进行血管内治疗后发生的延迟（15 天）组织学和超微结构变化，并比较结果以确定哪种技术危害最小，哪些技术危害最小。发生变化。材料和方法 在使用 Penumbra 系统或使用各种 SR 进行血栓切除术后评估猪颅外动脉壁的损伤。该程序使用两只猪作​​为动物模型进行；根据直径选择颅外颈动脉，以重现人颅内动脉的过程，并在注射自体血栓后进行血管内血栓切除术。两周后，动物被安乐死，并获得60个动脉样本进行光学和电子显微镜分析。结果 光学和电子显微镜显示，这两种技术都会以不同的方式改变血管壁的结构。结论 两种技术都对血管壁造成了损害。主要损伤位于中膜和外膜水平，而不是急性期的内膜。需要进一步调查以更好地了解这些改变是否会产生慢性后果。主要损伤位于中膜和外膜水平，而不是急性期的内膜。需要进一步调查以更好地了解这些改变是否会产生慢性后果。主要损伤位于中膜和外膜水平，而不是急性期的内膜。需要进一步调查以更好地了解这些改变是否会产生慢性后果。