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Advances of functional nanomaterials for cancer immunotherapeutic applications.
WIREs Nanomedicine and Nanobiotechnology ( IF 8.6 ) Pub Date : 2019-09-30 , DOI: 10.1002/wnan.1574
Yuhao Hao 1, 2 , Xingyu Zhou 1, 2 , Rui Li 1, 2 , Zechenxi Song 1, 2 , Yuanzeng Min 1, 2, 3
Affiliation  

Immunotherapy has made great progress by modulating the body's own immune system to fight against cancer cells. However, the low response rates of related drugs limit the development of immunotherapy strategies. Fortunately, the advantages of nanotechnology can just make up for this shortcoming. Nanocarriers of diverse systems are utilized to co-deliver antigens and adjuvants, combined with drugs for immunomodulatory, such as chemotherapy, radiotherapy, and photodynamic. Here we review recent studies on immunotherapy with biomimetic, organic, and inorganic nanomaterials. They are going to potentially overcome the drawbacks in cancer immunotherapy with delivering immunomodulatory drugs, delivering cancer vaccine, and monitoring the immune systems. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

中文翻译:

功能纳米材料在癌症免疫治疗中的应用进展。

免疫疗法通过调节人体自身的免疫系统对抗癌细胞而取得了长足的进步。然而,相关药物的低响应率限制了免疫疗法策略的发展。幸运的是,纳米技术的优势可以弥补这一不足。利用各种系统的纳米载体共同递送抗原和佐剂,并结合用于免疫调节的药物,例如化学疗法,放射疗法和光动力疗法。在这里,我们回顾了有关仿生,有机和​​无机纳米材料免疫疗法的最新研究。他们将通过提供免疫调节药物,提供癌症疫苗和监测免疫系统来克服癌症免疫疗法中的弊端。本文的特点是:治疗方法和药物发现>
更新日期:2019-11-01
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