当前位置: X-MOL 学术Bio-Medical Mater. Eng. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Efficacy of HYADD®4-G single intra-discal injections in a rabbit model of intervertebral disc degeneration.
Bio-Medical Materials and Engineering ( IF 1 ) Pub Date : 2019-01-01 , DOI: 10.3233/bme-191062
Atsuya Watanabe 1 , Pierre Mainil-Varlet 2 , Adeline Decambron 3 , Caroline Aschinger 2 , Antonella Schiavinato 4
Affiliation  

BACKGROUND Various biomaterials/technologies have been tested for treatment of intervertebral disc (IVD) degeneration (IDD). Only few non-surgical options exist. OBJECTIVE Assessment of efficacy and safety of the hyaluronic acid derivative hydrogel HYADD®4-G in IDD using a well-established rabbit annular puncture model. METHODS Rabbits were punctured at two IVDs to induce IDD. Thirty days after, IVDs were injected with HYADD®4-G or saline. IVD hydration, height, appearance and tissue organization were assessed by radiographs, MRI and histopathology. Safety of HYADD®4-G injection was evaluated in non-punctured IVDs. RESULTS HYADD®4-G injection restored disc height to over 75% of the pre-punctured disc, saline injections led to 50% of initial disc height. Compared to saline, HYADD®4-G treatment resulted in improved water retention as revealed by MRI quantification. 83.3% of HYADD®4-G injected discs had normal appearance and reached grade I of the Pfirrmann scale. Regarding tissue organization and cellularity, HYADD®4-G treatment resulted in significantly lower IDD scores than saline (p < 0.01). HYADD®4-G injected into healthy IVDs did not induce inflammation or foreign body reactions. CONCLUSIONS Intra-discal HYADD®4-G injection is safe and has therapeutic benefits: IDD could be limited through restoration of disc height and hydration and maintenance of normal IVD tissue organization.

中文翻译:

HYADD®4-G椎间盘内单次注射在兔椎间盘退变模型中的功效。

背景技术已经测试了各种生物材料/技术来治疗椎间盘退变(IDD)。仅存在少数非手术选择。目的使用成熟的兔环形穿刺模型评估透明质酸衍生物水凝胶HYADD®4-G在IDD中的疗效和安全性。方法在两个IVD处穿刺兔子以诱导IDD。30天后,向IVD注射4-G或盐水。通过射线照相,MRI和组织病理学评估IVD的水合作用,高度,外观和组织组织。在未穿刺的IVD中评估了HYADD®4-G注射的安全性。结果HYADD®4-G注射可将椎间盘高度恢复到预先穿刺的椎间盘的75%以上,盐水注射可导致初始椎间盘高度的50%。与生理盐水相比 MRI定量显示,HYADD®4-G处理可改善保水性。注入HYADD®4-G的椎间盘的外观正常,达到Pfirrmann等级I级。关于组织和细胞结构,HYADD®4-G治疗导致IDD评分明显低于生理盐水(p <0.01)。注入健康IVD中的HYADD®4-G不会引起炎症或异物反应。结论椎间盘内HYADD®4-G注射是安全的,并具有治疗益处:IDD可通过恢复椎间盘高度和水合作用以及维持正常IVD组织的组织受到限制。HYADD®4-G治疗导致IDD评分明显低于生理盐水(p <0.01)。注入健康IVD的HYADD®4-G不会引起炎症或异物反应。结论椎间盘内HYADD®4-G注射是安全的,并具有治疗益处:IDD可通过恢复椎间盘高度和水合作用以及维持正常IVD组织的组织受到限制。HYADD®4-G治疗导致IDD评分明显低于生理盐水(p <0.01)。注入健康IVD中的HYADD®4-G不会引起炎症或异物反应。结论椎间盘内HYADD®4-G注射是安全的,并具有治疗益处:IDD可通过恢复椎间盘高度和水合作用以及维持正常IVD组织的组织受到限制。
更新日期:2019-11-01
down
wechat
bug