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A comprehensive review on recent preparation techniques of liposomes
Journal of Liposome Research ( IF 4.4 ) Pub Date : 2019-09-27 , DOI: 10.1080/08982104.2019.1668010
C Has 1 , P Sunthar 1
Affiliation  

Abstract Liposomes (or lipid vesicles) are a versatile platform as carriers for the delivery of the drugs and other macromolecules into human and animal bodies. Though the method of using liposomes has been known since 1960s, and major developments and commercialization of liposomal formulations took place in the late nineties (or early part of this century), newer methods of liposome synthesis and drug encapsulation continue to be an active area of research. With the developments in related fields, such as electrohydrodynamics and microfluidics, and a growing understanding of the mechanisms of lipid assembly from colloidal and intermolecular forces, liposome preparation techniques have been enriched and more predictable than before. This has led to better methods that can also scale at an industrial production level. In this review, we present several novel methods that were introduced over the last decade and compare their advantages over conventional methods. Researchers beginning to explore liposomal formulations will find this resource useful to give an overall direction for an appropriate choice of method. Where possible, we have also provided the known mechanisms behind the preparation methods.

中文翻译:

近期脂质体制备技术综述

摘要 脂质体(或脂质囊泡)是一种多功能平台,可作为将药物和其他大分子递送到人体和动物体内的载体。尽管使用脂质体的方法自 1960 年代以来就已为人所知,并且脂质体制剂的重大开发和商业化发生在 90 年代后期(或本世纪初期),但脂质体合成和药物封装的新方法仍然是一个活跃的领域。研究。随着相关领域的发展,如电流体动力学和微流体学,以及从胶体和分子间作用力对脂质组装机制的日益了解,脂质体制备技术比以前更加丰富和更可预测。这导致了更好的方法,这些方法也可以在工业生产水平上扩展。在这次审查中,我们介绍了过去十年中引入的几种新方法,并比较了它们相对于传统方法的优势。Researchers beginning to explore liposomal formulations will find this resource useful to give an overall direction for an appropriate choice of method. 在可能的情况下,我们还提供了制备方法背后的已知机制。
更新日期:2019-09-27
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