The genetic material of every organism exists within the context of regulatory networks that govern gene expression, collectively called the epigenome. Epigenetics has taken center stage in the study of diseases such as cancer and diabetes, but its integration into the field of environmental health is still emerging. As the Environmental Mutagenesis and Genomics Society (EMGS) celebrates its 50th Anniversary this year, we have come together to review and summarize the seminal advances in the field of environmental epigenomics. Specifically, we focus on the role epigenetics may play in multigenerational and transgenerational transmission of environmentally induced health effects. We also summarize state of the art techniques for evaluating the epigenome, environmental epigenetic analysis, and the emerging field of epigenome editing. Finally, we evaluate transposon epigenetics as they relate to environmental exposures and explore the role of noncoding RNA as biomarkers of environmental exposures. Although the field has advanced over the past several decades, including being recognized by EMGS with its own Special Interest Group, recently renamed Epigenomics, we are excited about the opportunities for environmental epigenetic science in the next 50 years. Environ. Mol. Mutagen. 61:176-192, 2020. © 2019 Wiley Periodicals, Inc.

中文翻译：

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环境暴露和表观基因组在健康和疾病中的作用。

每个生物的遗传物质都存在于控制基因表达的调控网络（统称为表观基因组）的环境中。表观遗传学已成为癌症和糖尿病等疾病研究的中心阶段，但其整合到环境健康领域的研究仍在不断涌现。随着环境诱变和基因组学协会（EMGS）今年庆祝其成立50周年，我们聚集在一起回顾并总结了环境表观基因组学领域的开创性进展。具体而言，我们关注表观遗传学在环境诱导的健康影响的多代和跨代传播中可能发挥的作用。我们还总结了评估表观基因组，环境表观遗传学分析和表观基因组编辑的新兴领域的最新技术。最后，我们评估与环境暴露相关的转座子表观遗传学，并探讨非编码RNA作为环境暴露生物标志物的作用。尽管该领域在过去的几十年中一直在发展，包括被EMGS认可并拥有自己的特殊兴趣小组（最近更名为Epigenomics），但我们对未来50年内环境表观遗传学的机会感到兴奋。环境。大声笑 诱变剂。61：176-192，2020.©2019 Wiley Periodicals，Inc. 我们对未来50年内环境表观遗传学的机会感到兴奋。环境。大声笑 诱变剂。61：176-192，2020.©2019 Wiley Periodicals，Inc. 我们对未来50年内环境表观遗传学的机会感到兴奋。环境。大声笑 诱变剂。61：176-192，2020.©2019 Wiley Periodicals，Inc.