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Vitamin D supplementation decreases immune activation and exhaustion in HIV-1-infected youth.
Antiviral Therapy ( IF 1.2 ) Pub Date : 2017-10-11 , DOI: 10.3851/imp3199
Allison Ross Eckard 1, 2 , Mary Ann O'Riordan 3 , Julia C Rosebush 2 , Seungeun Thera Lee 2 , Jakob G Habib 2 , Joshua H Ruff 2 , Danielle Labbato 3 , Julie E Daniels 2 , Monika Uribe-Leitz 2 , Vin Tangpricha 2 , Ann Chahroudi 2 , Grace A McComsey 3
Affiliation  

Heightened immune activation and exhaustion drive HIV disease progression and comorbidities. Vitamin D has pleiotropic immunomodulatory effects, but little is known about the effects of supplementation in HIV. Our study investigates changes in immune activation and exhaustion markers after 12 months of supplementation in virologically suppressed HIV-infected youth with vitamin D insufficiency.

中文翻译:

补充维生素 D 可减少 HIV-1 感染青少年的免疫激活和疲劳。

免疫激活和衰竭的加剧会导致艾滋病毒疾病的进展和合并症。维生素 D 具有多效性免疫调节作用,但补充维生素 D 对 HIV 的作用却知之甚少。我们的研究调查了病毒学受到抑制且维生素 D 不足的 HIV 感染青少年服用补充剂 12 个月后免疫激活和耗竭标志物的变化。
更新日期:2020-08-21
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