Direct antiviral agents (DAA) demonstrated high efficacy among HCV-infected patients in registered trials. Nevertheless, the impact of these therapies on liver stiffness measurement (LSM) and liver functionality in 'real-life' is not well-known. The aim of the present study was to evaluate the sustained virological response (SVR) impact on LSM and clinical parameters of DAA-therapy on a real-life population of HCV patients with F3/F4 fibrosis.

中文翻译：

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HCV中直接抗病毒药物对病毒的持续应答导致肝纤维化的早期显着改善。

在注册试验中，直接抗病毒剂（DAA）在HCV感染患者中显示出高疗效。然而，这些疗法对“现实生活”中的肝硬度测量（LSM）和肝功能的影响尚不为人所知。本研究的目的是评估对F3 / F4纤维化的HCV患者的真实人群的持续病毒学应答（SVR）对LSM和DAA治疗的临床参数的影响。