Expression of inflammatory (interleukin-6 [IL-6]) and vascular homeostatic (angiopoietin-2 [AP-2], endothelin-1 [ET-1], endocan-2 [EC-2]) biomarkers in pediatric traumatic brain injury (TBI) was examined in this prospective, observational cohort study of 28 children hospitalized with mild, moderate, and severe TBI by clinical measures (age, sex, Glasgow Coma Scale score [GCS], Injury Severity Score [ISS], and cerebral autoregulation status). Biomarker patterns suggest an inverse relationship between GCS and AP-2, GCS and IL-6, ISS and ET-1, but a direct relationship between GCS and ET-1 and ISS and AP-2. Biomarker patterns suggest an inverse relationship between AP-2 and ET-1, AP-2 and EC-2, but a direct relationship between AP-2 and IL-6, IL-6 and EC-2, and IL-6 and ET-1. Plasma concentrations of inflammatory and vascular homeostatic biomarkers suggest a role for inflammation and disruption of vascular homeostasis during the first 10 days across the severity spectrum of pediatric TBI. Although not statistically significant, without impact on cerebral autoregulation, biomarker patterns suggest a relationship between inflammation and alterations in vascular homeostasis. The large variation in biomarker levels within TBI severity and age groups, and by sex suggests other contributory factors to biomarker expression.

中文翻译：

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小儿脑外伤后炎症和血管稳态的生物标志物之间的血浆水平，时间趋势和临床关联。

炎性（白细胞介素6 [IL-6]）和血管稳态（血管生成素2 [AP-2]，内皮素-1 [ET-1]，内皮糖2 [EC-2]）在小儿脑外伤中的表达（TBI）在这项前瞻性观察性队列研究中，通过临床指标（年龄，性别，格拉斯哥昏迷量表评分[GCS]，损伤严重程度评分[ISS]和脑自动调节）对28例轻，中度和重度TBI住院的儿童进行了检查状态）。生物标志物模式表明，GCS和AP-2，GCS和IL-6，ISS和ET-1之间呈反比关系，但GCS和ET-1和ISS和AP-2之间呈直接关系。生物标志物模式表明AP-2与ET-1，AP-2与EC-2之间呈反比关系，但AP-2与IL-6，IL-6与EC-2，IL-6与ET之间呈直接关系-1。炎症和血管稳态生物标志物的血浆浓度表明，在整个儿科TBI严重程度谱图的前10天中，炎症和血管稳态的破坏均起作用。尽管在统计学上不显着，并且不影响大脑的自动调节，但生物标志物模式表明炎症与血管稳态的改变之间存在关联。TBI严重程度和年龄组内生物标志物水平的巨大差异，以及性别差异，提示生物标志物表达的其他促成因素。生物标志物的模式表明炎症与血管动态平衡的改变之间存在关系。TBI严重程度和年龄组内生物标志物水平的巨大差异，以及按性别划分，提示生物标志物表达的其他促成因素。生物标志物的模式表明炎症与血管动态平衡的改变之间存在关系。TBI严重程度和年龄组内生物标志物水平的巨大差异，以及按性别划分，提示生物标志物表达的其他促成因素。