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The complex existence of γδ T cells following transplantation: the good, the bad and the simply confusing.
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2019-09-25 , DOI: 10.1002/cti2.1078
Lucy C Sullivan 1, 2 , Evangeline M Shaw 1 , Sanda Stankovic 1 , Gregory I Snell 2 , Andrew G Brooks 1 , Glen P Westall 2
Affiliation  

Gamma delta (γδ) T cells are a highly heterogeneous population of lymphocytes that exhibit innate and adaptive immune properties. Despite comprising the majority of residing lymphocytes in many organs, the role of γδ T cells in transplantation outcomes is under-researched. γδ T cells can recognise a diverse array of ligands and exert disparate effector functions. As such, they may potentially contribute to both allograft acceptance and rejection, as well as impacting on infection and post-transplant malignancy. Here, we review the current literature on the role and function of γδ T cells following solid organ and hematopoietic stem cell transplantation.

中文翻译:

移植后γδT细胞的复杂存在:好,坏和简单的混淆。

伽玛三角洲(γδ)T细胞是高度异质的淋巴细胞群体,具有先天性和适应性免疫特性。尽管在许多器官中包含大部分驻留的淋巴细胞,但对γδT细胞在移植结果中的作用仍在研究中。γδT细胞可以识别各种配体并发挥不同的效应子功能。因此,它们可能潜在地促进同种异体移植的接受和排斥,以及对感染和移植后恶性肿瘤的影响。在此,我们回顾了有关实体器官和造血干细胞移植后γδT细胞的作用和功能的最新文献。
更新日期:2019-11-01
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