Background: Prader-Willi syndrome (PWS) is a neurodevelopmental genetic disorder involving executive deficits notably with planning. The main objective of the study is to assess the effectiveness of cognitive training on daily life planning difficulties in PWS patients.

Methods/design: The study is a double-blind randomized controlled trial which will compare the effectiveness of a metacognitive strategy intervention designed to improve planning difficulties for PWS patients to usual occupational therapy. Sixty adults will be included over 20 months. The main outcome measure will be the performance on the Modified Six Elements Test from the BADS; secondary outcome measures will be computerized executive tasks and questionnaires. Daily life planning difficulties will be identified and transformed into measurable goals using Goal Attainment Scaling.

Discussion: The project will provide knowledge on the difficulties experienced by PWS patients, in relation to their executive functioning in order to implement effective intervention for planning in daily life.

背景：Prader-Willi综合征（PWS）是一种神经发育性遗传疾病，涉及执行缺陷，尤其是在计划中。该研究的主要目的是评估认知训练对PWS患者日常生活计划困难的有效性。

方法/设计：这项研究是一项双盲随机对照试验，该试验将比较旨在改善PWS患者计划困难的元认知策略干预措施与常规职业治疗的有效性。在20个月内将包括60名成人。主要结果指标将是BADS的“改进的六要素”测试的表现；次要结果测量将通过计算机执行任务和问卷进行。日常生活计划的困难将被识别，并使用“目标达标”来转化为可衡量的目标。

讨论：该项目将提供有关PWS患者在执行功能方面遇到的困难的知识，以便对计划中的生活进行有效干预。