Background: An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative. Methods: The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings. Results: The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding. Conclusions: This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

中文翻译：

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瑞士遗传性乳腺癌、卵巢癌和林奇综合征的癌症易感性级联筛查的挑战和机遇：国际研讨会的结果

背景：关于遗传性乳腺癌和卵巢癌 (HBOC) 和林奇综合征 (LS) 的癌症易感性级联遗传筛查国际研讨会在瑞士举行，来自不同学科的级联筛查和遗传性癌症的领先研究人员和临床医生参加了会议。研讨会的目的是加强瑞士级联遗传筛查的实施。参与者讨论了与瑞士 HBOC 和 LS 级联筛查相关的挑战和机遇（CASCADE 研究）；家庭影响和基于家庭的干预措施的必要性；需要评估级联遗传筛查的成本效益；和跨专业合作需要领导这一举措。方法：研讨会的目标是通过交流荷兰、澳大利亚和美国俄亥俄州成功的级联筛选计划的数据和经验来实现的；支持瑞士癌症级联筛查的瑞士研究和科学经验；社会心理肿瘤学和家庭研究的研究计划；荷兰和澳大利亚之前对级联遗传筛查的成本效益分析的数据；以及来自大型跨专业合作的组织经验。记录了科学演示并综合了讨论以展示研讨会的结果。结果：成功实施级联遗传筛查的关键要素是利益相关者的支持网络和与互补举措的联系；样本量和亲属招募；集中组织服务；基于数据的成本效益分析；倡议组织透明；和持续的资助。结论：本文描述了癌症易感性级联筛查国际研讨会的过程和主要发现，该研讨会将指导瑞士的 CASCADE 研究。