Surface electrical stimulation has the potential to be a powerful and non-invasive treatment for a variety of medical conditions but currently it is difficult to obtain consistent evoked responses. A viable clinical system must be able to adapt to variations in individuals to produce repeatable results. To more fully study the effect of these variations without performing exhaustive testing on human subjects, a system of computer models was created to predict motor and sensory axon activation in the median nerve due to surface electrical stimulation at the elbow. An anatomically-based finite element model of the arm was built to accurately predict voltages resulting from surface electrical stimulation. In addition, two axon models were developed based on previously published models to incorporate physiological differences between sensory and motor axons. This resulted in axon models that could reproduce experimental results for conduction velocity, strength-duration curves and activation threshold. Differences in experimentally obtained action potential shape between the motor and sensory axons were reflected in the models. The models predicted a lower threshold for sensory axons than motor axons of the same diameter, allowing a range of sensory axons to be activated before any motor axons. This system of models will be a useful tool for development of surface electrical stimulation as a method to target specific neural functions.

中文翻译：

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使用表面电刺激的正中神经运动和感觉轴突激活模型。

表面电刺激可能会成为多种医学状况的有力且非侵入性的治疗方法，但目前很难获得一致的诱发反应。可行的临床系统必须能够适应个体差异以产生可重复的结果。为了在不对人类受试者进行详尽测试的情况下更全面地研究这些变异的影响，创建了一个计算机模型系统，以预测由于肘部表面电刺激而引起的正中神经的运动轴突和感觉轴突活化。建立了基于解剖学的手臂有限元模型，以准确预测表面电刺激产生的电压。此外，根据先前发布的模型开发了两个轴突模型，以纳入感觉轴突和运动轴突之间的生理差异。这导致了轴突模型，该模型可以重现传导速度，强度-持续时间曲线和激活阈值的实验结果。模型中反映了运动轴突和感觉轴突之间实验获得的动作电位形状的差异。该模型预测，与相同直径的运动轴突相比，感觉轴突的阈值更低，从而允许在任何运动轴突之前激活一定范围的感觉轴突。该模型系统将是开发表面电刺激作为靶向特定神经功能的一种有用工具。强度持续时间曲线和激活阈值。模型中反映了运动轴突和感觉轴突之间实验获得的动作电位形状的差异。该模型预测，与相同直径的运动轴突相比，感觉轴突的阈值更低，从而允许在任何运动轴突之前激活一定范围的感觉轴突。该模型系统将是开发表面电刺激作为靶向特定神经功能的一种有用工具。强度持续时间曲线和激活阈值。模型中反映了运动轴突和感觉轴突之间实验获得的动作电位形状的差异。该模型预测，与相同直径的运动轴突相比，感觉轴突的阈值更低，从而允许在任何运动轴突之前激活一定范围的感觉轴突。该模型系统将是开发表面电刺激作为靶向特定神经功能的一种有用工具。