Although the efficacy of combination therapy with lamivudine or tenofovir and pegylated interferon (PEG-IFN) has been reported in patients with chronic hepatitis B (CHB), the long-term effect of the combination based on the observation of clinical course remains to be clarified. We previously reported the efficacy of combination therapy with entecavir (ETV) and PEG-IFN. Here, we investigated the long-term effect of this combination in patients with CHB.

中文翻译：

---

恩替卡韦联合聚乙二醇干扰素治疗慢性乙型肝炎后，具有持续的抗病毒作用和清除肝炎表面抗原的作用。

尽管已经报道了拉米夫定或替诺福韦与聚乙二醇干扰素（PEG-IFN）联合治疗慢性乙型肝炎（CHB）患者的疗效，但根据临床病程观察，联合治疗的长期效果尚待阐明。我们先前报道了恩替卡韦（ETV）和PEG-IFN联合治疗的疗效。在这里，我们调查了这种组合对CHB患者的长期疗效。