Systemic capillary leak syndrome (SCLS) is a rare disorder characterized by capillary leakage of plasma fluids throughout the endothelium. The mechanism of SCLS is still unknown. Vascular endothelial growth factor (VEGF), an inducer or barrier disruption, is markedly upregulated in SCLS. This study was to investigate the molecular mechanisms involving SCLS-related inflammation and neuron damage in SCLS remain unclear. Data files of GSE97287 dataset were extracted and processed for identification of differentially expressed genes (DEGs), including upregulated adrenomedullin (ADM) gene, hypoxia-inducible factor-1α (HIF-1α) and VEGFA; and downregulated aldehyde dehydrogenase 1A1 (ALDH1A1) gene and interleukin (IL)-2 receptor β (IL-2RB) gene. Weighted gene coexpression network analysis (WGCNA) was performed for DEGs and four significant modules were identified and were enriched Gene Ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways related to immune response, angiogenesis, neuroblast proliferation, HIF-1 signaling pathway, and Parkinson's disease. The activated HIF-1α/VEGFA signaling in SCLS patients might well be responsible for the impaired inflammatory, nervous, and immune systems.

中文翻译：

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生物信息学分析证实激活的 HIF-1α/VEGFA 信号通路在全身毛细血管渗漏综合征中的关键调节作用。

全身性毛细血管渗漏综合征 (SCLS) 是一种罕见的疾病，其特征是整个内皮中血浆液体的毛细血管渗漏。SCLS的机制尚不清楚。血管内皮生长因子 ( VEGF ) 是一种诱导剂或屏障破坏剂，在 SCLS 中显着上调。本研究旨在探讨 SCLS 中涉及 SCLS 相关炎症和神经元损伤的分子机制尚不清楚。提取并处理GSE97287数据集的数据文件以鉴定差异表达基因（DEGs），包括上调肾上腺髓质素（ADM）基因、缺氧诱导因子1α（HIF-1α）和VEGFA；和下调的醛脱氢酶 1A1 ( ALDH1A1) 基因和白细胞介素 (IL)-2 受体 β ( IL-2RB ) 基因。对 DEG 进行加权基因共表达网络分析 (WGCNA) 并确定了四个重要模块，并丰富了与免疫反应、血管生成、神经母细胞增殖、HIF 相关的基因本体论 (GO) 生物过程和京都基因和基因组百科全书 (KEGG) 通路-1 信号通路和帕金森病。SCLS 患者中激活的HIF-1α/VEGFA信号很可能是炎症、神经和免疫系统受损的原因。