This study evaluated the effect of the topical application of melatonin mixed with collagenized porcine bone on the osteointegration on the rough discrete calcium deposit (DCD) surface implants in Beagle dogs 3 months after their insertion. In preparation for subsequent insertion of dental implants, lower molars were extracted from 12 Beagle dogs. Each mandible received two parallel wall expanded platform implants with a DCD surface of 4 mm in diameter and 10 mm in length. The implants were randomly assigned to the distal sites on each mandible in the molar area and the gaps were filled with 5 mg lyophilized powdered melatonin and porcine bone and collagenized porcine bone alone. Ten histological sections per implant were obtained for histomorphometric studies. After a 4-wk treatment period, melatonin plus porcine bone significantly increased the perimeter of bone that was in direct contact with the treated implants (P < 0.0001), bone density (P < 0.0001), and new bone formation (P < 0.0001) in comparison with porcine bone alone around the implants. Melatonin plus collagenized porcine bone on DCD surface may act as a biomimetic agent in the placement of endo-osseous dental implants and enhance the osteointegration. Melatonin combined with porcine bone on DCD implants reveals more bone in implant contact at 12 wk (84.5 +/- 1.5%) compared with porcine bone alone treated area (67.17 +/- 1.2%).

中文翻译：

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褪黑激素与胶原化猪骨混合与猪骨仅对牙种植体骨整合的作用。

本研究评估了局部应用褪黑激素与胶原化猪骨混合对 Beagle 犬植入 3 个月后粗糙离散钙沉积 (DCD) 表面植入物骨整合的影响。为了准备随后插入牙种植体，从 12 只比格犬身上拔出下臼齿。每个下颌骨都接受了两个平行的壁扩展平台植入物，其 DCD 表面直径为 4 毫米，长度为 10 毫米。种植体被随机分配到磨牙区每个下颌骨的远端部位，间隙填充 5 mg 冻干粉状褪黑激素和猪骨和胶原化猪骨。每个植入物获得十个组织切片用于组织形态学研究。经过 4 周的治疗期后，与单独使用猪骨相比，褪黑激素加猪骨显着增加了与处理过的种植体直接接触的骨周长（P < 0.0001）、骨密度（P < 0.0001）和新骨形成（P < 0.0001）。植入物。DCD 表面的褪黑激素加胶原化猪骨可作为仿生剂用于骨内种植体的植入并增强骨整合。DCD 种植体上的褪黑激素与猪骨结合显示，与单独处理猪骨的区域（67.17 +/- 1.2%）相比，在 12 周时种植体接触的骨量更多（84.5 +/- 1.5%）。DCD 表面的褪黑激素加胶原化猪骨可作为仿生剂用于骨内种植体的植入并增强骨整合。DCD 种植体上的褪黑激素与猪骨结合显示，与单独处理猪骨的区域（67.17 +/- 1.2%）相比，在 12 周时种植体接触的骨量更多（84.5 +/- 1.5%）。DCD 表面的褪黑激素加胶原化猪骨可作为仿生剂用于骨内种植体的植入并增强骨整合。DCD 种植体上的褪黑激素与猪骨结合显示，与单独处理猪骨的区域（67.17 +/- 1.2%）相比，在 12 周时种植体接触的骨量更多（84.5 +/- 1.5%）。