Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall and normally adopt a quiescent, contractile phenotype. VSMC migration is tightly controlled, however, disease associated changes in the soluble and insoluble environment promote VSMC migration. Classically, studies investigating VSMC migration have described the influence of soluble factors. Emerging data has highlighted the importance of insoluble factors, including extracellular matrix stiffness and porosity. In this review, we will recap on the important signalling pathways that regulate VSMC migration and reflect on the potential importance of emerging regulators of VSMC function.

中文翻译：

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血管平滑肌细胞迁移的新兴监管机构。

血管平滑肌细胞 (VSMC) 是血管壁中的主要细胞类型，通常采用静止、收缩表型。VSMC 迁移受到严格控制，然而，可溶性和不可溶性环境中与疾病相关的变化会促进 VSMC 迁移。传统上，调查 VSMC 迁移的研究描述了可溶性因子的影响。新兴数据强调了不溶性因素的重要性，包括细胞外基质硬度和孔隙率。在这篇综述中，我们将回顾调节 VSMC 迁移的重要信号通路，并反思 VSMC 功能的新兴监管机构的潜在重要性。