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Two decades (1998-2018) of research Progress on Hormesis: advancing biological understanding and enabling novel applications.
Journal of Cell Communication and Signaling ( IF 4.1 ) Pub Date : 2019-04-17 , DOI: 10.1007/s12079-019-00517-7
Walter J Kozumbo 1 , Edward J Calabrese 2
Affiliation  

This commentary briefly summarizes the extraordinary resurgence of hormesis within the biological, biomedical, toxicological and risk assessment domains over the past two decades. It places this resurgence within the context of challenging the scientific validity of the threshold and linear dose responses. It argues that conducting research on mechanisms that actuate and regulate the stimulatory response features of hormesis will provide the knowledge needed to develop potentially transformational applications aimed at protecting and enhancing biological resiliency as well as treating/curing a multitude of diverse medical conditions.

中文翻译:

兴奋剂研究进展的二十年(1998-2018):增进生物学理解并实现新颖的应用。

这篇评论简要总结了过去二十年来在生物,生物医学,毒理学和风险评估领域内兴奋剂异常兴起的现象。它使这种复苏成为挑战阈值和线性剂量反应的科学有效性的背景。它认为,对促动和调节兴奋剂反应特征的机制进行研究将提供开发潜在的转化性应用所需的知识,这些应用旨在保护和增强生物适应性以及治疗/治愈多种多样的医学病症。
更新日期:2019-04-17
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