Individuation and organization in complex living multi-level ecosystem occurs as dynamical processes from early ontogeny. The notion of living “holon” displaying dynamic self-assertion and integration is used here to explain the ecosystems dynamic processes. The update of the living holon state according to the continuous change of the dynamic system allows for its viability. This is interpreted as adaptation, selection and organization by the human that observes the system a posteriori from its level. Our model concerns the complex dynamics of the adaptive immune system, integrating holon-lymphocytes that collectively preserve the identity and integrity of the organism. Each lymphocyte individualizes as a dynamic holon-lymphocyte, with somatic gene individuation leading to an individual, singular antigen immunoreceptor type, promoting the self-assertion. In turn, the “Immunoception” allows for perception of the environmental antigenic context, thus integration of the holon in its environment. The self-assertion/integration of holon-lymphocyte starts from fetal stages and is influenced by mother Lamarckian acquired historicity transmissions, a requisite for the integrity of the holobiont-organism. We propose a dynamic model of the perception by holon-lymphocyte, and at the supra-clonal level of the immune system functions that sustain the identity and integrity of the holon-holobiont organism.

中文翻译：

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复杂生命生态系统中的个体化和组织化：Holon-淋巴细胞的递归整合和自我主张

复杂生活多层次生态系统中的个体化和组织作为早期个体发育的动态过程发生。展示动态自我主张和整合的活“完整”概念在这里被用来解释生态系统的动态过程。根据动态系统的不断变化更新活的完全子状态允许其生存。这被解释为人类从系统的水平后验观察系统的适应、选择和组织。我们的模型涉及适应性免疫系统的复杂动力学，整合整体保持生物体身份和完整性的完整淋巴细胞。每个淋巴细胞个体化为一个动态的完整淋巴细胞，体细胞基因个体化导致个体、单一的抗原免疫受体类型，促进自我主张。反过来，“免疫感受”允许感知环境抗原背景，从而将完全子整合到其环境中。完整淋巴细胞的自我主张/整合从胎儿阶段开始，并受到母亲拉马克获得的历史性传播的影响，这是完整生物体完整性的必要条件。我们提出了一个完整的淋巴细胞感知的动态模型，并且在维持完整完整生物体的身份和完整性的免疫系统功能的超克隆水平上。完整淋巴细胞的自我主张/整合从胎儿阶段开始，并受到母亲拉马克获得的历史性传播的影响，这是完整生物体完整性的必要条件。我们提出了一个完整的淋巴细胞感知的动态模型，并且在维持完整完整生物体的身份和完整性的免疫系统功能的超克隆水平上。完整淋巴细胞的自我主张/整合从胎儿阶段开始，并受到母亲拉马克获得的历史性传播的影响，这是完整生物体完整性的必要条件。我们提出了一个完整的淋巴细胞感知的动态模型，并且在维持完整完整生物体的身份和完整性的免疫系统功能的超克隆水平上。