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Thymoquinone ameliorates obesity-induced metabolic dysfunction, improves reproductive efficiency exhibiting a dose-organ relationship.
Systems Biology in Reproductive Medicine ( IF 2.4 ) Pub Date : 2019-07-01 , DOI: 10.1080/19396368.2019.1626933
Seba Harphoush 1, 2, 3 , Guoqing Wu 1, 3 , Gao Qiuli 1 , Margaret Zaitoun 1, 2, 3 , Maissam Ghanem 1, 2, 3 , Yonghui Shi 1, 3 , Guowei Le 1, 3
Affiliation  

Women with obesity are more likely to have a complicated reproductive life. Insulin resistance and metabolic dysfunction are associated with obesity. Thymoquinone (TQ) is a well-known antioxidant, considered to be an AMPK-activator. The goal of this work was to investigate the ability of TQ to improve fertility and lactation and clarify the possible mechanism. Female C57BL/6 mice were subjected to High Fat Diet (HFD) supplemented with TQ (10% pmm) and TQ (20% pmm). Histopathological examination was conducted on mammary and ovarian samples. Metabolic and oxidant status was evaluated, and qRT-PCR analysis was performed to verify AMPK/PGC1α/SIRT1 metabolic pathway activity. The present study reports positive effects of TQ on ovarian metabolic function in a dose-dependent manner. TQ showed its positive effects on mammary gland metabolic function at lower dose. This is the first study that indicates these dose related impacts of TQ.

Abbreviations: AKT1: serine-threonine protein kinase 1; AMPK: 5′ AMP-activated protein kinase; CAT: catalase; CON: control; FBS: fasting blood sugar; GLUT1: glucose transporter 1; GSH: reduced glutathione; GSSG: Glutathione disulfide; HE: hematoxylin and eosin stains; HDL: high-density lipoprotein; HFD: high fat diet; IL-6: interleukin-6; K18: keratin 18; LD: lactation day; LDL: low-density lipoprotein; LKB1: serine-threonine liver kinase B1; MDA: malondialdehyde; mTOR: the mammalian target of rapamycin; NAD: nicotinamide adenine dinucleotide; NADH: nicotinamide adenine dinucleotide phosphate; NS: nigella sativa; PBS: phosphate-buffered saline; PGC1α: peroxisome proliferator-activated receptor gamma coactivator 1-alpha; SIRT1: sirtuin 1; SOD: superoxide dismutase; T-AOC: total antioxidants; TFAM: transcription factor A mitochondrial; TG: triglycerides; TNF-α: tumor necrosis factor-α; TQ: thymoquinone; TQ10: high fat diet + thymoquinone 10% ppm; TQ20: high fat diet + thymoquinone 20% ppm; UCP2: uncoupling Protein 2.



中文翻译:

胸腺醌可改善肥胖引起的代谢功能障碍,提高生殖效率,表现出剂量-器官关系。

肥胖妇女更可能具有复杂的生殖生活。胰岛素抵抗和代谢功能障碍与肥胖有关。胸腺醌(TQ)是一种众所周知的抗氧化剂,被认为是AMPK活化剂。这项工作的目的是研究TQ改善生育力和泌乳能力的能力,并阐明可能的机制。对雌性C57BL / 6小鼠进行高脂饮食(HFD),其中补充了TQ(10%pmm)和TQ(20%pmm)。对乳腺和卵巢样本进行了组织病理学检查。评估代谢和氧化剂状态,并进行qRT-PCR分析以验证AMPK /PGC1α/ SIRT1代谢途径的活性。本研究以剂量依赖的方式报道了TQ对卵巢代谢功能的积极影响。TQ在较低剂量下显示出对乳腺代谢功能的积极作用。这是第一项表明TQ剂量相关影响的研究。

缩略语:AKT1:丝氨酸-苏氨酸蛋白激酶1;AMPK:5'AMP激活的蛋白激酶;CAT:过氧化氢酶;CON:控制;FBS:空腹血糖;GLUT1:葡萄糖转运蛋白1;GSH:还原型谷胱甘肽;GSSG:谷胱甘肽二硫化物;HE:苏木精和曙红染色;HDL:高密度脂蛋白;HFD:高脂饮食;IL-6:白介素6;K18:角蛋白18;LD:哺乳日;LDL:低密度脂蛋白;LKB1:丝氨酸-苏氨酸肝激酶B1;MDA:丙二醛;mTOR:雷帕霉素的哺乳动物靶标;NAD:烟酰胺腺嘌呤二核苷酸;NADH:烟酰胺腺嘌呤二核苷酸磷酸;NS:苜蓿;PBS:磷酸盐缓冲液;PGC1α:过氧化物酶体增殖物激活受体γ共激活物1-alpha;SIRT1:sirtuin 1;SOD:超氧化物歧化酶;T-AOC:总抗氧化剂;TFAM:转录因子A线粒体;TG:甘油三酸酯;TNF-α:肿瘤坏死因子-α;TQ:胸腺醌;TQ10:高脂饮食+胸腺嘧啶10%ppm;TQ20:高脂饮食+胸腺醌20%ppm;UCP2:解偶联蛋白2。

更新日期:2019-07-01
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