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Mild hyperbaric oxygen: mechanisms and effects.
The Journal of Physiological Sciences ( IF 2.3 ) Pub Date : 2019-05-08 , DOI: 10.1007/s12576-019-00678-5 Akihiko Ishihara 1
The Journal of Physiological Sciences ( IF 2.3 ) Pub Date : 2019-05-08 , DOI: 10.1007/s12576-019-00678-5 Akihiko Ishihara 1
Affiliation
Adequate oxygen supply by exposure to mild hyperbaric oxygen at appropriately high atmospheric pressure (1266-1317 hPa) and increased oxygen concentration (35-40% oxygen) has a possibility of improving the oxidative metabolism in cells and tissues without barotrauma and excessive production of reactive oxygen species. Therefore, metabolic syndrome and lifestyle-related diseases, including type 2 diabetes and hypertension, in rats were inhibited and/or improved by exposure to mild hyperbaric oxygen. It accelerated the growth-induced increase in oxidative capacity of the skeletal muscle in rats and inhibited the age-related decrease in oxidative capacity of the skeletal muscle in mice. A decrease in dopaminergic neurons in the substantia nigra of mice with Parkinson's disease was inhibited by exposure to mild hyperbaric oxygen. This review describes the beneficial effects of exposure to mild hyperbaric oxygen on some metabolic diseases and their perspectives.
中文翻译:
轻度高压氧:机理和作用。
通过在适当高的气压(1266-1317 hPa)下暴露于轻度高压氧中并提供充足的氧气浓度(35-40%氧气)来提供充足的氧气,可能会改善细胞和组织中的氧化代谢,而不会产生气压伤和过度产生反应性氧气种类。因此,暴露于轻度高压氧可抑制和/或改善大鼠的代谢综合征和与生活方式有关的疾病,包括2型糖尿病和高血压。它加速了大鼠骨骼肌氧化能力的生长诱导增加,并抑制了小鼠骨骼肌氧化能力的年龄相关性下降。暴露于轻度高压氧可抑制帕金森氏病小鼠黑质中多巴胺能神经元的减少。
更新日期:2019-11-01
中文翻译:
轻度高压氧:机理和作用。
通过在适当高的气压(1266-1317 hPa)下暴露于轻度高压氧中并提供充足的氧气浓度(35-40%氧气)来提供充足的氧气,可能会改善细胞和组织中的氧化代谢,而不会产生气压伤和过度产生反应性氧气种类。因此,暴露于轻度高压氧可抑制和/或改善大鼠的代谢综合征和与生活方式有关的疾病,包括2型糖尿病和高血压。它加速了大鼠骨骼肌氧化能力的生长诱导增加,并抑制了小鼠骨骼肌氧化能力的年龄相关性下降。暴露于轻度高压氧可抑制帕金森氏病小鼠黑质中多巴胺能神经元的减少。