Alzheimer's disease is a progressive, irreversible, incurable, neurodegenerative illness and the most common of the dementing disorders. It starts usually after 60 years of age and may span 8 to 12 years. The continuous and slow decline caused by this disease, is characterized by cognitive deterioration, loss of functional independence, changes in behaviour, and expanding needs for care. In the last three decades, the proteins predominating neuritic plaques and neurofibrillary tangles have been detected and researched: amyloid-beta protein in the plaques and hyperphosphorylated tau in the tangles. Alzheimer's disease is now considered a long-term process with a slow progress and with a prolonged development of pathological changes that precedes symptoms by years. AD is becoming one of the most problematic and expensive illness for the civilization, also known as "silent threat".

中文翻译：

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阿尔茨海默氏病的临床方面。

阿尔茨海默氏病是一种进行性，不可逆转，无法治愈的神经退行性疾病，是最常见的痴呆症。它通常在60岁以后开始，可能会持续8到12年。由这种疾病引起的持续而缓慢的下降，其特征是认知能力下降，功能独立性丧失，行为改变以及对护理的需求不断扩大。在过去的三十年中，已经检测到并研究了神经炎性斑块和神经原纤维缠结中主要的蛋白质：斑块中的淀粉样β蛋白和缠结中的tau蛋白过度磷酸化。现在，阿尔茨海默氏病被认为是一个长期的过程，进展缓慢，病理改变的发展时间长于症状出现数年。