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Brainwaves Oscillations as a Potential Biomarker for Major Depression Disorder Risk
Clinical EEG and Neuroscience ( IF 2 ) Pub Date : 2019-09-20 , DOI: 10.1177/1550059419876807
Patricia Fernández-Palleiro 1 , Tania Rivera-Baltanás 1 , Daniela Rodrigues-Amorim 1 , Sonia Fernández-Gil 1 , María Del Carmen Vallejo-Curto 1 , María Álvarez-Ariza 1 , Marta López 1 , Cynthia Rodriguez-Jamardo 1 , Jose Luis Benavente 1 , Elena de Las Heras 1 , José Manuel Olivares 1 , Carlos Spuch 1
Affiliation  

Major depressive disorder (MDD) is a multidimensional disorder that is characterized by the presence of alterations in mood, cognitive capacity, sensorimotor, and homeostatic functions. Given that about half of the patients diagnosed with MDD do not respond to the various current treatments, new techniques are being sought to predict not only the course of the disease but also the characteristics that differentiate responders from non-responders. Using the electroencephalogram, a noninvasive and inexpensive tool, most studies have proposed that patients with MDD have some lateralization in brain electrical activity, with alterations in alpha and theta rhythms being observed, which would be related to dysfunctions in emotional capacity such as the absence or presence of responses to the different existing treatments. These alterations help in the identification of subjects at high risk of suffering from depression, in the differentiation into responders and nonresponders to various therapies (pharmacological, electroconvulsive therapy, and so on), as well as to establish in which period of the disease the treatment will be more effective. Although the data are still inconclusive and more research is needed, these alpha and theta neurophysiological markers could support future clinical practice when it comes to establishing an early diagnosis and treating state disorders more successfully and accurately of mood disorders.

中文翻译:

脑电波振荡作为严重抑郁症风险的潜在生物标志物

重度抑郁症 (MDD) 是一种多维障碍,其特征是情绪、认知能力、感觉运动和稳态功能的改变。鉴于大约一半被诊断患有 MDD 的患者对当前的各种治疗没有反应,因此正在寻求新技术来预测疾病的进程,以及区分反应者和无反应者的特征。使用脑电图(一种无创且廉价的工具),大多数研究表明,MDD 患者的脑电活动存在一定程度的偏侧化,观察到 alpha 和 theta 节律的改变,这可能与情绪能力的功能障碍有关,例如缺乏或存在对不同现有治疗的反应。这些改变有助于识别患有抑郁症的高风险受试者,区分对各种疗法(药物、电休克疗法等)有反应者和无反应者,以及确定治疗的疾病时期会更有效。尽管数据仍不确定,需要更多研究,但这些 alpha 和 theta 神经生理学标记可以支持未来的临床实践,以便更成功、更准确地建立情绪障碍的早期诊断和治疗状态障碍。以及确定治疗在疾病的哪个时期更有效。尽管数据仍不确定,需要更多研究,但这些 alpha 和 theta 神经生理学标记可以支持未来的临床实践,以便更成功、更准确地建立情绪障碍的早期诊断和治疗状态障碍。以及确定治疗在疾病的哪个时期更有效。尽管数据仍不确定,需要更多研究,但这些 alpha 和 theta 神经生理学标记可以支持未来的临床实践,以便更成功、更准确地建立情绪障碍的早期诊断和治疗状态障碍。
更新日期:2019-09-20
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