INTRODUCTION Interleukin 33 (IL-33) is a pleiotropic cytokine involved in pathological processes in seasonal allergic rhinitis. IL-33 binds to ST2 receptor, which is highly expressed on mast cells and selectively on Th2 cells. Information is lacking on the role of IL-33/ST2 axis in allergen subcutaneous immunotherapy. AIM OF THE STUDY To determine if allergen immunotherapy changes the IL-33/ST2l axis in seasonal allergic rhinitis patients. MATERIAL AND METHODS 40 patients with intermittent allergic rhinitis sensitive to grass and/or tree pollen were studied. Among these, 10 patients were longitudinally assessed in the follow-up visit after completing the first course of immunotherapy. Twenty-two healthy subjects were included as controls. Immunotherapy was applied according to a perennial schedule comprising up-building and maintenance phases. Serum levels of ST2/IL-33 R and IL-33 were measured by ELISA (R&D Systems). RESULTS Serum levels of IL-33 significantly rose after the first course of immunotherapy and reached the controls levels. Serum levels of ST2 were comparable before the pollen season and after the first course of immunotherapy. CONCLUSIONS Increase in serum levels of IL-33 after the first course of immunotherapy may suggest it is too short period to prevent the expected raise in serum IL-33 levels in the pollen season, and longer treatment is required to observe significant changes of this cytokine. ST2 serum levels are independent of immunotherapy and pollen season.

中文翻译：

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间歇性过敏性鼻炎皮下过敏原免疫治疗患者血清白细胞介素 33 及其受体 ST2 水平。

简介 白细胞介素 33 (IL-33) 是一种多效性细胞因子，参与季节性过敏性鼻炎的病理过程。IL-33 与 ST2 受体结合，该受体在肥大细胞上高度表达，并选择性地在 Th2 细胞上表达。缺乏关于 IL-33/ST2 轴在过敏原皮下免疫治疗中的作用的信息。研究目的 确定过敏原免疫疗法是否会改变季节性过敏性鼻炎患者的 IL-33/ST2l 轴。材料与方法 对 40 例对草和/或树花粉敏感的间歇性变应性鼻炎患者进行了研究。其中，10名患者在完成第一疗程免疫治疗后的随访中进行了纵向评估。包括 22 名健康受试者作为对照。免疫疗法是根据包括建立和维护阶段的常年时间表应用的。通过 ELISA (R&D Systems) 测量 ST2/IL-33 R 和 IL-33 的血清水平。结果免疫治疗第一疗程后血清IL-33水平显着升高并达到对照组水平。ST2 的血清水平在花粉季节之前和免疫治疗的第一个疗程之后相当。结. ST2 血清水平与免疫疗法和花粉季节无关。ST2 的血清水平在花粉季节之前和免疫治疗的第一个疗程之后相当。结. ST2 血清水平与免疫疗法和花粉季节无关。ST2 的血清水平在花粉季节之前和免疫治疗的第一个疗程之后相当。结. ST2 血清水平与免疫疗法和花粉季节无关。